TY - JOUR
T1 - Association between Perceived Dysphagia Symptoms and Swallowing Physiology in Parkinson's Disease
AU - Rangwala, Rabab
AU - Bahia, Mariana Mendes
AU - Song, Jing
AU - Bega, Danny
AU - Martin-Harris, Bonnie
N1 - : R.R. is employed at Northwestern University and University of California San Francisco. M.M.B. is employed at Northwestern University and University of Illinois Urbana\u2010Champaign and has received grants from the American Speech\u2010Language\u2010Hearing Foundation, and the Shirley Ryan Ability Lab. J.S. is employed at Northwestern University Feinberg School of Medicine. D.B. is employed at Northwestern University Feinberg School of Medicine; is a part of the speaker's bureau for Teva Pharmaceuticals, Neurocrine Biosciences, Supernus Pharmaceuticals, Acorda Therapeutics, and AbbVie Pharmaceuticals; is a consultant for GLG and Clearview Consulting; receives honoraria from the American Academy of Neurology, and the American Neurological Association; and has received grants from the Huntington Disease Society of America and the Parkinson Foundation. B.M.H. is employed at Northwestern University, has received a NIH/NCI, 1R01CA262502\u201001 (PI: B.M.H.), a NIH/NIDCD, 2K24DC12801\u201007 (PI: B.M.H.), a NIH/NIDDK R01DK122975\u201001 (Sub\u2010PI: B.M.H.), a Machine Vision Fellowship Grant, Bracco Diagnostics, 2019\u20132026 (PI: B.M.H.), has copyright royalties from Northern Speech Services through agreement with Medical University of South Carolina and is a joint inventor of a US provisional patent, Feb 16, 2018: US 62/710,324. Funding Disclosures for the Previous 12 Months
: This research study has partially been supported by The Michael J. Fox Foundation for Parkinson's Research (Grant ID: MJFF\u2010009650, PI: B.M.H.) and the National Institute on Deafness and Other Communication Disorders at the National Institutes of Health (NIH/NIDCD 2K24DC012801\u20130; PI: B.M.H.) Statistical analysis was supported by a Northwestern University Graduate Research Grant (Recipient: R.R.). The authors declare that there are no conflicts of interest relevant to this work. Funding Sources and Conflict of Interest
PY - 2025/10
Y1 - 2025/10
N2 - Background: Swallowing disorders are prevalent in Parkinson's disease (PD). Swallowing assessment often relies on patient-reported outcome measures (PROMs). Although PROMs and physiologic swallowing measures correlate with disease severity, the relationship between PROMs and physiologic swallowing impairments is unclear. Objectives: Our aim was to (1) delineate the relationship between perceived swallowing symptoms and physiologic swallowing impairments; and (2) determine the relationship between swallowing-related quality of life (QoL) and physiologic impairments. Methods: A total of 31 individuals with PD (mean age = 64.8, standard deviation = 9.4) and dysphagia were recruited. PROMs included the Sydney Swallow Questionnaire (SSQ) and Swallowing Quality of Life Survey (SWAL-QOL) to measure perceived swallowing-related symptoms and QoL, respectively. Participants underwent a Modified Barium Swallow Study (MBSS) to obtain physiologic swallowing measures, including the Modified Barium Swallow Impairment Profile (MBSImP) and Penetration-Aspiration Scale (PAS). Multiple linear regression analyses assessed the associations between PROMs and physiologic measures, controlling for disease duration. Results: Perceived swallowing difficulties indicated mild to moderate symptoms (SSQ: 20–871.5), and perceived swallowing-related QoL showed moderate to no impact (SWAL-QOL: 52.5%–100%). Swallowing components oral residue (97%) and delayed pharyngeal swallow (97%) were the most frequently impaired on the MBSImP. Furthermore, 45.2% of participants showed airway invasion (PAS ≥3) in at least one swallow trial. Regression analysis showed significant associations between MBSImP pharyngeal total score with SSQ (P < 0.001, R2 = 0.49) and SWAL-QOL (P = 0.014, R2 = 0.36). Conclusions: These findings suggest that PROMs may not fully capture all aspects of physiological swallowing impairments. Relying solely on PROMs may overlook critical swallowing deficits not perceived by the patient, highlighting the need for objective swallowing assessments in PD.
AB - Background: Swallowing disorders are prevalent in Parkinson's disease (PD). Swallowing assessment often relies on patient-reported outcome measures (PROMs). Although PROMs and physiologic swallowing measures correlate with disease severity, the relationship between PROMs and physiologic swallowing impairments is unclear. Objectives: Our aim was to (1) delineate the relationship between perceived swallowing symptoms and physiologic swallowing impairments; and (2) determine the relationship between swallowing-related quality of life (QoL) and physiologic impairments. Methods: A total of 31 individuals with PD (mean age = 64.8, standard deviation = 9.4) and dysphagia were recruited. PROMs included the Sydney Swallow Questionnaire (SSQ) and Swallowing Quality of Life Survey (SWAL-QOL) to measure perceived swallowing-related symptoms and QoL, respectively. Participants underwent a Modified Barium Swallow Study (MBSS) to obtain physiologic swallowing measures, including the Modified Barium Swallow Impairment Profile (MBSImP) and Penetration-Aspiration Scale (PAS). Multiple linear regression analyses assessed the associations between PROMs and physiologic measures, controlling for disease duration. Results: Perceived swallowing difficulties indicated mild to moderate symptoms (SSQ: 20–871.5), and perceived swallowing-related QoL showed moderate to no impact (SWAL-QOL: 52.5%–100%). Swallowing components oral residue (97%) and delayed pharyngeal swallow (97%) were the most frequently impaired on the MBSImP. Furthermore, 45.2% of participants showed airway invasion (PAS ≥3) in at least one swallow trial. Regression analysis showed significant associations between MBSImP pharyngeal total score with SSQ (P < 0.001, R2 = 0.49) and SWAL-QOL (P = 0.014, R2 = 0.36). Conclusions: These findings suggest that PROMs may not fully capture all aspects of physiological swallowing impairments. Relying solely on PROMs may overlook critical swallowing deficits not perceived by the patient, highlighting the need for objective swallowing assessments in PD.
KW - Parkinson's disease
KW - dysphagia
KW - modified barium swallow impairment profile
KW - patient-reported outcome measures
KW - swallowing
UR - https://www.scopus.com/pages/publications/105005776831
UR - https://www.scopus.com/pages/publications/105005776831#tab=citedBy
U2 - 10.1002/mdc3.70129
DO - 10.1002/mdc3.70129
M3 - Article
C2 - 40396298
AN - SCOPUS:105005776831
SN - 2330-1619
VL - 12
SP - 1571
EP - 1581
JO - Movement Disorders Clinical Practice
JF - Movement Disorders Clinical Practice
IS - 10
ER -