TY - JOUR
T1 - Association between birth interval and cardiovascular outcomes at 30 years of age
T2 - A prospective cohort study from Brazil
AU - Devakumar, D.
AU - Hallal, P. C.
AU - Horta, B. L.
AU - Barros, F. C.
AU - Wells, J. C.K.
N1 - Funding Information:
The authors received no specific funding for this work. The cohort study was funded by the Wellcome Trust; the International Development Research Center (Canada); the Brazilian National Research Council (CNPq); Rio Grande do Sul State Research Support Foundation (FAPERGS); and the Brazilian Ministry of Health. The study is based on data from the study "Pelotas Birth Cohort, 1982" done by the Postgraduate Program in Epidemiology at Universida de Federal de Pelotas, with the collaboration of the Brazilian Public Health Association (ABRASCO). From 2004 to 2013, the Wellcome Trust supported the 1982 birth cohort study. The International Development Research Center, World Health Organization, Overseas Development Administration, European Union, National Support Program for Centers of Excellence (PRONEX), CNPq, FAPERGS, and the Brazilian Ministry of Health supported previous phases of the study. PCH is funded by the Wellcome Trust through a New Investigator Award. DD receives salary support from the National Institute for Health Research.
Publisher Copyright:
© 2016 Devakumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/2
Y1 - 2016/2
N2 - Background Birth interval is an important and potentially modifiable factor that is associated with child health. Whether an association exists with longer-term outcomes in adults is less well known. Methods: Using the 1982 Pelotas (Brazil) Birth Cohort Study, the association of birth interval with markers of cardiovascular health at 30 years of age was examined. Multivariable linear regression was used with birth interval as a continuous variable and categorical variable, and effect modification by gender was explored. Results: Birth interval and cardiovascular data were present for 2,239 individuals. With birth interval as a continuous variable, no association was found but stratification by gender tended to show stronger associations for girls. When compared to birth intervals of <18 months, as binary variable, longer intervals were associated with increases in height (1.6 cm; 95% CI: 0.5,2.8) and lean mass (1.7 kg; 95% CI: 0.2,3.2). No difference was seen with other cardiovascular outcomes. Conclusion: s: An association was generally not found between birth interval and cardiovascular outcomes at 30 years of age, though some evidence existed for differences between males and females and for an association with height and lean mass for birth intervals of 18 months and longer.
AB - Background Birth interval is an important and potentially modifiable factor that is associated with child health. Whether an association exists with longer-term outcomes in adults is less well known. Methods: Using the 1982 Pelotas (Brazil) Birth Cohort Study, the association of birth interval with markers of cardiovascular health at 30 years of age was examined. Multivariable linear regression was used with birth interval as a continuous variable and categorical variable, and effect modification by gender was explored. Results: Birth interval and cardiovascular data were present for 2,239 individuals. With birth interval as a continuous variable, no association was found but stratification by gender tended to show stronger associations for girls. When compared to birth intervals of <18 months, as binary variable, longer intervals were associated with increases in height (1.6 cm; 95% CI: 0.5,2.8) and lean mass (1.7 kg; 95% CI: 0.2,3.2). No difference was seen with other cardiovascular outcomes. Conclusion: s: An association was generally not found between birth interval and cardiovascular outcomes at 30 years of age, though some evidence existed for differences between males and females and for an association with height and lean mass for birth intervals of 18 months and longer.
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U2 - 10.1371/journal.pone.0149054
DO - 10.1371/journal.pone.0149054
M3 - Article
C2 - 26890250
AN - SCOPUS:84960516920
SN - 1932-6203
VL - 11
JO - PloS one
JF - PloS one
IS - 2
M1 - e0149054
ER -