Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound

Parth Patwari, Neil J. Weissman, Stephen A. Boppart, Christine Jesser, Debra Stamper, James G. Fujimoto, Mark E. Brezinski

Research output: Contribution to journalArticlepeer-review


This study compares the ability of intravascular optical coherence tomography (OCT) and high-frequency intravascular ultrasound (IVUS) to image highly stenotic human coronary arteries in vitro. Current imaging modalities have insufficient resolution to perform risk stratification based on coronary plaque morphology. OCT is a new technology capable of imaging at a resolution of 5 to 20 μm, which has demonstrated the potential for coronary arterial imaging in prior experiments. Human postmortem coronary arteries with severely stenotic segments were imaged with catheter-based OCT and IVUS. The OCT system had an axial resolution of 20 μm and a transverse resolution of 30 μm. OCT was able to penetrate and image near-occlusive coronary plaques. Compared with IVUS, these OCT images demonstrated superior delineation of vessel layers and lack of ring-down artifact, leading to clearer visualization of the vessel plaque and intima. Histology confirmed the accuracy and high contrast of vessel layer boundaries seen on OCT images. Thus, catheter-based OCT systems are able to image near-occlusive coronary plaques with higher resolution than that of IVUS.

Original languageEnglish (US)
Article number7752
Pages (from-to)641-644
Number of pages4
JournalAmerican Journal of Cardiology
Issue number5
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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