Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle

Jae Yoon Shin, Jae Il Shin, Jun Seob Kim, Yoo Soo Yang, Yunha Hwang, Joo Sung Yang, Dongwoo Shin, Jin Ho Seo, Yong Su Jin, Yong Cheol Park, Jae Sung Hwang, Dae Hyuk Kweon

Research output: Contribution to journalArticle

Abstract

There are tremendous drug candidates that suffer from insolubility in water. In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I). Similar to the way that apoA-I forms nascent discoidal high density lipoprotein (ndHDL) particles by bordering acyl chain tails of phospholipids, CoQ10 could be enclosed into the circle of a disk made of apoA-Is. The resulting nanostructure of CoQ10 and apoA-I was water-soluble with a size of ∼12 nm in diameter and was physically more robust than liposome. We expect that the strategy suggested in this study can be exploited to assemble nano-sized, water-soluble structures of various water-insoluble drug candidates.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume388
Issue number2
DOIs
StatePublished - Oct 16 2009

Keywords

  • apoA-I
  • Coenzyme Q10
  • High density lipoprotein
  • Nanoparticle

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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  • Cite this

    Shin, J. Y., Shin, J. I., Kim, J. S., Yang, Y. S., Hwang, Y., Yang, J. S., Shin, D., Seo, J. H., Jin, Y. S., Park, Y. C., Hwang, J. S., & Kweon, D. H. (2009). Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle. Biochemical and Biophysical Research Communications, 388(2), 217-221. https://doi.org/10.1016/j.bbrc.2009.07.140