Assaying neurotransmitters in and around single neurons with information-rich detectors

Robin L. Dahlgren; Jason S. Page; Jonathan V. Sweedler

doi:10.1016/S0003-2670(99)00606-6

Assaying neurotransmitters in and around single neurons with information-rich detectors

Robin L. Dahlgren, Jason S. Page, Jonathan V. Sweedler

Research output: Contribution to journal › Article › peer-review

Abstract

Techniques to study the chemical environment in and around individual neurons are reviewed, with an emphasis on methods to assay single cells for neurotransmitters and neuromodulators that do not require analyte preselection. Current capabilities of capillary-based microseparations and mass spectrometry are highlighted for this application. Methods to combine multiple analytical techniques to provide chemical, spatial and temporal information are described. Copyright (C) 1999 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	13-26
Number of pages	14
Journal	Analytica Chimica Acta
Volume	400
Issue number	1-3
DOIs	https://doi.org/10.1016/S0003-2670(99)00606-6
State	Published - Nov 22 1999

Keywords

Capillary electrophoresis
Capillary separations
ESI
MALDI
Mass spectrometry
Single cell assay

ASJC Scopus subject areas

Biochemistry
Analytical Chemistry
Spectroscopy
Environmental Chemistry

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10.1016/S0003-2670(99)00606-6

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title = "Assaying neurotransmitters in and around single neurons with information-rich detectors",

abstract = "Techniques to study the chemical environment in and around individual neurons are reviewed, with an emphasis on methods to assay single cells for neurotransmitters and neuromodulators that do not require analyte preselection. Current capabilities of capillary-based microseparations and mass spectrometry are highlighted for this application. Methods to combine multiple analytical techniques to provide chemical, spatial and temporal information are described. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "Capillary electrophoresis, Capillary separations, ESI, MALDI, Mass spectrometry, Single cell assay",

author = "Dahlgren, {Robin L.} and Page, {Jason S.} and Sweedler, {Jonathan V.}",

note = "Funding Information: We gratefully acknowledge the support of the USA National Institutes of Health through grant NS31609 and the National Science Foundation (CHE 9877071).",

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AU - Sweedler, Jonathan V.

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AB - Techniques to study the chemical environment in and around individual neurons are reviewed, with an emphasis on methods to assay single cells for neurotransmitters and neuromodulators that do not require analyte preselection. Current capabilities of capillary-based microseparations and mass spectrometry are highlighted for this application. Methods to combine multiple analytical techniques to provide chemical, spatial and temporal information are described. Copyright (C) 1999 Elsevier Science B.V.

KW - Capillary electrophoresis

KW - Capillary separations

KW - ESI

KW - MALDI

KW - Mass spectrometry

KW - Single cell assay

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Assaying neurotransmitters in and around single neurons with information-rich detectors

Abstract

Keywords

ASJC Scopus subject areas

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