Techniques to study the chemical environment in and around individual neurons are reviewed, with an emphasis on methods to assay single cells for neurotransmitters and neuromodulators that do not require analyte preselection. Current capabilities of capillary-based microseparations and mass spectrometry are highlighted for this application. Methods to combine multiple analytical techniques to provide chemical, spatial and temporal information are described. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)13-26
Number of pages14
JournalAnalytica Chimica Acta
Issue number1-3
StatePublished - Nov 22 1999


  • Capillary electrophoresis
  • Capillary separations
  • ESI
  • Mass spectrometry
  • Single cell assay

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry


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