Abstract
Aryl-aldehydes are a common feature in fungal polyketides, which are considered to be exclusively generated by the R domain of nonreducing polyketide synthases (NR-PKSs). However, by cloning and heterologous expression of both cryptic NR-PKS and nonribosomal peptide synthase (NRPS)-like genes from Aspergillus terreus in Saccharomyces cerevisiae, we identified a distinct mechanism for aryl-aldehyde formation in which a NRPS-like protein activates and reduces an aryl-acid produced by the accompanying NR-PKS to an aryl-aldehyde. Bioinformatics study indicates that such a mechanism may be widely used throughout the fungi kingdom.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 257-263 |
| Number of pages | 7 |
| Journal | Chemistry and Biology |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 20 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry
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Wang, M., Beissner, M., & Zhao, H. (2014). Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism. Chemistry and Biology, 21(2), 257-263. https://doi.org/10.1016/j.chembiol.2013.12.005