Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism

Meng Wang, Mirko Beissner, Huimin Zhao

Research output: Contribution to journalArticle

Abstract

Aryl-aldehydes are a common feature in fungal polyketides, which are considered to be exclusively generated by the R domain of nonreducing polyketide synthases (NR-PKSs). However, by cloning and heterologous expression of both cryptic NR-PKS and nonribosomal peptide synthase (NRPS)-like genes from Aspergillus terreus in Saccharomyces cerevisiae, we identified a distinct mechanism for aryl-aldehyde formation in which a NRPS-like protein activates and reduces an aryl-acid produced by the accompanying NR-PKS to an aryl-aldehyde. Bioinformatics study indicates that such a mechanism may be widely used throughout the fungi kingdom.

Original languageEnglish (US)
Pages (from-to)257-263
Number of pages7
JournalChemistry and Biology
Volume21
Issue number2
DOIs
StatePublished - Feb 20 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism'. Together they form a unique fingerprint.

  • Cite this