Arterial stiffness and walk time in patients with end-stage renal disease

Abbi D. Lane, Pei Tzu Wu, Brandon Kistler, Peter Fitschen, Emily Tomayko, Jin Hee Jeong, Hae Ryung Chung, Huimin Yan, Sushant M. Ranadive, Shane Phillips, Bo Fernhall, Kenneth Wilund

Research output: Contribution to journalArticlepeer-review


Background: End-stage renal disease patients experience increased prevalence of cardiovascular disease. Heart-artery interaction may be shifted, impacting blood pressure lability, and exercise tolerance. The coupling ratio consists of the ratio of indexed arterial elastance (EaI, arterial load) to ElvI, a measure of cardiac contractility or stiffness. Our purpose was to explore the relationship between elastances and functional capacity. We hypothesized that arterial stiffness (central pulse wave velocity, PWV) and elastances would be correlated to shuttle walk time. Methods: We used applanation tonometry, ultrasonography, and a shuttle walk test to evaluate our hypothesis. Spearman's correlations were used to assess relationships between variables. Block regression was also performed. Results: Forty-two subjects on maintenance hemodialysis participated. Average age=44±5 years, body surface area=2.01 kg/m2. Mean EaI=4.45 and mean ElvI=6.89; the coupling ratio=0.82. Mean aortic pulse pressure=51 mmHg and PWV=9.6 m/s. PWV(r=-0.385) and EaI (r=-0.424) were significantly and inversely related to walking time while stroke volume index (SVI) was positively correlated to shuttle walk time (r=0.337), p<0.05 for all. Conclusions: We conclude that, like other clinical populations, both arterial and heart function predict walking ability and represent potential targets for intervention; arterial stiffness and SVI are strongly related to shuttle walk time in patients with ESRD.

Original languageEnglish (US)
Pages (from-to)142-150
Number of pages9
JournalKidney and Blood Pressure Research
Issue number2-3
StatePublished - May 2013


  • Arterial stiffness
  • ESRD
  • Shuttle walk

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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