@article{1a50b0e7aeb64da6a68f3560c2816322,
title = "Argon laser retinal lesions evaluated in vivo by optical coherence tomography",
abstract = "PURPOSE: To assess the in vivo evolution of argon laser retinal lesions by correlating the cross-sectional structure from sequential optical coherence tomography with histopathologic sectioning. METHODS: Argon laser lesions were created in the retinas of Macaca mulatta and evaluated by cross- section optical coherence tomography, which was compared at selected time points with corresponding histopathology. RESULTS: Argon laser lesions induced an optical coherence tomography pattern of early outer retinal relative high reflectivity with subsequent surrounding relative low reflectivity that correlated well with histopathologic findings. The in vivo optical coherence tomography images of macular laser lesions clearly demonstrated differences in pathologic response by retinal layer over time. CONCLUSION: The novel sequential imaging of rapidly evolving macular lesions with optical coherence tomography provides new insight into the patterns of acute tissue response by cross-sectional layer. This sequential imaging technique will aid in our understanding of the rapid evolution of retinal pathology and response to treatment in the research and clinical setting.",
author = "Toth, {C. A.} and R. Birngruber and Boppart, {S. A.} and Hee, {M. R.} and Fujimoto, {J. G.} and DiCarlo, {C. D.} and Swanson, {E. A.} and Cain, {C. P.} and Narayan, {D. G.} and Noojin, {G. D.} and Roach, {W. P.}",
note = "Funding Information: From the Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina (Dr Toth and Mr Narayan); Medizinisches Laserzentrum Liibeck, Liibeck, Germany (Dr Birngruber); Department of Electrical Engineering, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts (Mr Boppart, Mr Hee, and Dr Fujimoto), and Lincoln Laboratory (Dr Swanson); Uniformed Services University of the Health Sciences, Bethesda, Maryland (Dr DiCarlo); The Analytical Sciences Corporation, San Antonio, Texas (Dr Cain and Mr Noojin); and Air Force Office of Scientific Research, Chemistry and Life Science, Boiling AFB, District of Columbia (Dr Roach). This research was sponsored by USAF Armstrong Laboratory, the Air Force Office of Scientific Research, Air Force Systems Command, USAF, under grant numbers F49620-95-1-0226 and 2312AA-92AL014 and contract F33615-92-C-0017. The US Government is authorized to reproduce and distribute reprints for governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either express or implied, of the Air Force Office of Scientific Research (AFOSR) or the US Government.",
year = "1997",
doi = "10.1016/S0002-9394(14)71035-9",
language = "English (US)",
volume = "123",
pages = "188--198",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier Inc.",
number = "2",
}