Arenophile-Mediated Dearomative Functionalization Strategies

Mikiko Okumura, David Sarlah

Research output: Contribution to journalArticlepeer-review


The dearomatization of arenes is a fundamental synthetic strategy, providing a direct connection between simple hydrocarbons and valuable, more complex intermediates. While several strategies exist, the functionalization with concurrent introduction of functionality (i.e., dearomative functionalization) is still a largely underdeveloped field. This Synpacts article provides an overview and insights from our recent work in this area using small molecules-arenophiles. 1 Introduction 2 Arenophiles 3 Olefin-Like Dearomative Functionalizations 4 Arenophiles and Transition-Metal Catalysis 5 Applications in Natural Product Synthesis 6 Conclusion.

Original languageEnglish (US)
Article numberst-2018-p0023-sp
Pages (from-to)845-855
Number of pages11
Issue number7
StatePublished - Apr 23 2018


  • arenes
  • carbocycles
  • catalysis
  • cycloaddition
  • dearomatization
  • functionalization
  • natural products

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Arenophile-Mediated Dearomative Functionalization Strategies'. Together they form a unique fingerprint.

Cite this