Aptamers for Viral Detection and Inhibition

Banani Chakraborty; Sreyashi Das; Arushi Gupta; Yanyu Xiong; Vyshnavi T-V; Megan E. Kizer; Jinwei Duan; Arun Richard Chandrasekaran; Xing Wang

doi:10.1021/acsinfecdis.1c00546

Aptamers for Viral Detection and Inhibition

Banani Chakraborty, Sreyashi Das, Arushi Gupta, Yanyu Xiong, Vyshnavi T-V, Megan E. Kizer, Jinwei Duan, Arun Richard Chandrasekaran, Xing Wang

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent times have experienced more than ever the impact of viral infections in humans. Viral infections are known to cause diseases not only in humans but also in plants and animals. Here, we have compiled the literature review of aptamers selected and used for detection and inhibition of viral infections in all three categories: humans, animals, and plants. This review gives an in-depth introduction to aptamers, different types of aptamer selection (SELEX) methodologies, the benefits of using aptamers over commonly used antibody-based strategies, and the structural and functional mechanism of aptasensors for viral detection and therapy. The review is organized based on the different characterization and read-out tools used to detect virus-aptasensor interactions with a detailed index of existing virus-targeting aptamers. Along with addressing recent developments, we also discuss a way forward with aptamers for DNA nanotechnology-based detection and treatment of viral diseases. Overall, this review will serve as a comprehensive resource for aptamer-based strategies in viral diagnostics and treatment.

Original language	English (US)
Pages (from-to)	667-692
Number of pages	26
Journal	ACS Infectious Diseases
Volume	8
Issue number	4
DOIs	https://doi.org/10.1021/acsinfecdis.1c00546
State	Published - Apr 8 2022

Keywords

aptamers
aptasensors
DNA nanostructures
inhibition
sensing
viruses

ASJC Scopus subject areas

Infectious Diseases

Online availability

10.1021/acsinfecdis.1c00546

Library availability

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title = "Aptamers for Viral Detection and Inhibition",

abstract = "Recent times have experienced more than ever the impact of viral infections in humans. Viral infections are known to cause diseases not only in humans but also in plants and animals. Here, we have compiled the literature review of aptamers selected and used for detection and inhibition of viral infections in all three categories: humans, animals, and plants. This review gives an in-depth introduction to aptamers, different types of aptamer selection (SELEX) methodologies, the benefits of using aptamers over commonly used antibody-based strategies, and the structural and functional mechanism of aptasensors for viral detection and therapy. The review is organized based on the different characterization and read-out tools used to detect virus-aptasensor interactions with a detailed index of existing virus-targeting aptamers. Along with addressing recent developments, we also discuss a way forward with aptamers for DNA nanotechnology-based detection and treatment of viral diseases. Overall, this review will serve as a comprehensive resource for aptamer-based strategies in viral diagnostics and treatment. ",

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author = "Banani Chakraborty and Sreyashi Das and Arushi Gupta and Yanyu Xiong and Vyshnavi T-V and Kizer, {Megan E.} and Jinwei Duan and Chandrasekaran, {Arun Richard} and Xing Wang",

note = "Funding Information: B.C. thanks DBT India (BT/PR21542/NNT/28/1561/2018) and DBT Ramalingaswami for the support fellowship (BT//RLF/Re-entry/13/2013). M.E.K. thanks the NIH Postdoctoral fellowship (F32GM137477). J.D. thanks the Natural Science Foundation of Shaanxi Province (Nos. 2017JQ2035 and 2018JQ2023) and Fundamental Research Funds for the Central Universities (No. 300102129101). X.W. thanks the NIH NIAAA (AA029348), NIH NIAID (AI159454), NIH NIDCR (DE030852), and NSF RAPID (20-27778). Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",

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doi = "10.1021/acsinfecdis.1c00546",

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AU - Chakraborty, Banani

AU - Das, Sreyashi

AU - Gupta, Arushi

AU - Xiong, Yanyu

AU - T-V, Vyshnavi

AU - Kizer, Megan E.

AU - Duan, Jinwei

AU - Chandrasekaran, Arun Richard

AU - Wang, Xing

N1 - Funding Information: B.C. thanks DBT India (BT/PR21542/NNT/28/1561/2018) and DBT Ramalingaswami for the support fellowship (BT//RLF/Re-entry/13/2013). M.E.K. thanks the NIH Postdoctoral fellowship (F32GM137477). J.D. thanks the Natural Science Foundation of Shaanxi Province (Nos. 2017JQ2035 and 2018JQ2023) and Fundamental Research Funds for the Central Universities (No. 300102129101). X.W. thanks the NIH NIAAA (AA029348), NIH NIAID (AI159454), NIH NIDCR (DE030852), and NSF RAPID (20-27778). Publisher Copyright: © 2022 American Chemical Society. All rights reserved.

PY - 2022/4/8

Y1 - 2022/4/8

N2 - Recent times have experienced more than ever the impact of viral infections in humans. Viral infections are known to cause diseases not only in humans but also in plants and animals. Here, we have compiled the literature review of aptamers selected and used for detection and inhibition of viral infections in all three categories: humans, animals, and plants. This review gives an in-depth introduction to aptamers, different types of aptamer selection (SELEX) methodologies, the benefits of using aptamers over commonly used antibody-based strategies, and the structural and functional mechanism of aptasensors for viral detection and therapy. The review is organized based on the different characterization and read-out tools used to detect virus-aptasensor interactions with a detailed index of existing virus-targeting aptamers. Along with addressing recent developments, we also discuss a way forward with aptamers for DNA nanotechnology-based detection and treatment of viral diseases. Overall, this review will serve as a comprehensive resource for aptamer-based strategies in viral diagnostics and treatment.

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Aptamers for Viral Detection and Inhibition

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