Aptamers for Viral Detection and Inhibition

Banani Chakraborty, Sreyashi Das, Arushi Gupta, Yanyu Xiong, Vyshnavi T-V, Megan E. Kizer, Jinwei Duan, Arun Richard Chandrasekaran, Xing Wang

Research output: Contribution to journalReview articlepeer-review


Recent times have experienced more than ever the impact of viral infections in humans. Viral infections are known to cause diseases not only in humans but also in plants and animals. Here, we have compiled the literature review of aptamers selected and used for detection and inhibition of viral infections in all three categories: humans, animals, and plants. This review gives an in-depth introduction to aptamers, different types of aptamer selection (SELEX) methodologies, the benefits of using aptamers over commonly used antibody-based strategies, and the structural and functional mechanism of aptasensors for viral detection and therapy. The review is organized based on the different characterization and read-out tools used to detect virus-aptasensor interactions with a detailed index of existing virus-targeting aptamers. Along with addressing recent developments, we also discuss a way forward with aptamers for DNA nanotechnology-based detection and treatment of viral diseases. Overall, this review will serve as a comprehensive resource for aptamer-based strategies in viral diagnostics and treatment.

Original languageEnglish (US)
Pages (from-to)667-692
Number of pages26
JournalACS Infectious Diseases
Issue number4
StatePublished - Apr 8 2022


  • aptamers
  • aptasensors
  • DNA nanostructures
  • inhibition
  • sensing
  • viruses

ASJC Scopus subject areas

  • Infectious Diseases


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