Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Li Tang; Xujuan Yang; Lawrence W. Dobrucki; Isthier Chaudhury; Qian Yin; Catherine Yao; Stephane Lezmi; William G. Helferich; Timothy M. Fan; Jianjun Cheng

doi:10.1002/anie.201205271

Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Li Tang, Xujuan Yang, Lawrence W. Dobrucki, Isthier Chaudhury, Qian Yin, Catherine Yao, Stephane Lezmi, William G. Helferich, Timothy M. Fan, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

A dual-modal imaging probe based on size-controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates (see scheme) functionalized with an aptamer (green triangles) that targets 4T1 breast cancer cells improved the detection efficiency of sentinel lymph nodes with metastatic tumors.

Original language	English (US)
Pages (from-to)	12721-12726
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	51
DOIs	https://doi.org/10.1002/anie.201205271
State	Published - Dec 14 2012
Externally published	Yes

Keywords

aptamers
breast cancer
dual-modal imaging
metastasis targeting
nanoparticles

ASJC Scopus subject areas

General Chemistry
Catalysis

Online availability

10.1002/anie.201205271

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Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M., & Cheng, J. (2012). Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors. Angewandte Chemie - International Edition, 51(51), 12721-12726. https://doi.org/10.1002/anie.201205271

Tang, L, Yang, X, Dobrucki, LW, Chaudhury, I, Yin, Q, Yao, C, Lezmi, S, Helferich, WG , Fan, TM & Cheng, J 2012, 'Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors', Angewandte Chemie - International Edition, vol. 51, no. 51, pp. 12721-12726. https://doi.org/10.1002/anie.201205271

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abstract = "A dual-modal imaging probe based on size-controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates (see scheme) functionalized with an aptamer (green triangles) that targets 4T1 breast cancer cells improved the detection efficiency of sentinel lymph nodes with metastatic tumors.",

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author = "Li Tang and Xujuan Yang and Dobrucki, {Lawrence W.} and Isthier Chaudhury and Qian Yin and Catherine Yao and Stephane Lezmi and Helferich, {William G.} and Fan, {Timothy M.} and Jianjun Cheng",

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day = "14",

doi = "10.1002/anie.201205271",

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T1 - Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

AU - Tang, Li

AU - Yang, Xujuan

AU - Dobrucki, Lawrence W.

AU - Chaudhury, Isthier

AU - Yin, Qian

AU - Yao, Catherine

AU - Lezmi, Stephane

AU - Helferich, William G.

AU - Fan, Timothy M.

AU - Cheng, Jianjun

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KW - breast cancer

KW - dual-modal imaging

KW - metastasis targeting

KW - nanoparticles

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Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Abstract

Keywords

ASJC Scopus subject areas

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