Application of robotics to radiopharmaceutical preparation: controlled synthesis of fluorine-18 16 alpha-fluoroestradiol-17 beta.

J. W. Brodack, M. R. Kilbourn, M. J. Welch, J. A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review

Abstract

A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-[18F] fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of [18F]-tetrabutylammonium fluoride, SN2 displacement of a triflate, and ketone reduction) and is purified by high performance liquid chromatography (HPLC). All steps in the synthesis and HPLC purification are controlled by the robot system with no manual intervention. This represents a new approach to the complete automation of radiopharmaceutical production.

Original languageEnglish (US)
Pages (from-to)714-721
Number of pages8
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume27
Issue number5
StatePublished - May 1986

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Application of robotics to radiopharmaceutical preparation: controlled synthesis of fluorine-18 16 alpha-fluoroestradiol-17 beta.'. Together they form a unique fingerprint.

Cite this