Application of multivariable feedback methods to intravenous anesthetic pharmacodynamics

Geir Dullerud, Marie Csete, John Doyle

Research output: Contribution to journalConference articlepeer-review


Continuous infusions of intravenous anesthetics are becoming increasingly popular during surgical procedures, largely because relatively precise, consistent control of anesthetic depth is possible over intravenous injection techniques. In this paper we investigate the main issues involved with the development of automatic intravenous anesthesia delivery systems in the context of robust multivariable control. We present a pharmacodynamic model that may be suitable for closed-loop control, and discuss clinical data collected from human subjects during actual surgical conditions with the anesthetic propofol.

Original languageEnglish (US)
Pages (from-to)791-795
Number of pages5
JournalProceedings of the American Control Conference
StatePublished - 1995
Externally publishedYes
EventProceedings of the 1995 American Control Conference. Part 1 (of 6) - Seattle, WA, USA
Duration: Jun 21 1995Jun 23 1995

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


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