The structural control can provide the potential protection through passive and active control techniques. Structures with base isolations have been successfully implemented and proven effective in the vibration mitigation. To enhance the functionality of base isolations, a hybrid control system can be considered using a combination with active control devices. This research applies the hybrid control technique to a three-story two-bay steel building. The base isolation is installed under the structural base, and three actuators are placed at the lowest level. The control objective is to reduce the structural responses in the motion of three directions. First, the control system has been identified through the proposed system identification technique and considered with the control-structure interaction. Different controllers are designed to examine the performance under different types of excitation. Finally, this control system is tested on the shake table for evaluation of the controllers, and the two-dimensional control strategy is also realized through the whole procedures.