Appendicular osteosarcoma in small-breed dogs: 51 cases (1986-2011)

Pierre M. Amsellem, Laura Selmic, Jacqueline M Wypij, Nicholas J. Bacon, William T.N. Culp, Nicole P. Ehrhart, Barbara E. Powers, Henrik Stryhn, James P. Farese

Research output: Contribution to journalArticlepeer-review


Objective-To describe outcomes for small-breed dogs with appendicular osteosarcoma. Design-Multi-institutional retrospective case series. Animals-51 small-breed dogs. Procedures-Records from participating Veterinary Society of Surgical Oncology members were searched for dogs that weighed ≤ 15 kg (33 lb) with a histologic diagnosis of appendicular osteosarcoma. The Kaplan-Meier method was used to determine median survival times (MSTs), and Cox regression was performed to identify variables associated with survival time. Results-Tumors were most commonly located on the humerus (n = 15) and femur (14). Of the 51 study dogs, 9 were treated nonsurgically, 16 underwent amputation of the affected limb only, and 26 underwent curative-intent treatment, with MSTs of 112, 257, and 415 days, respectively. The MST did not differ significantly between dogs in the amputation-only and curative-intent groups. For dogs in the nonsurgical group, MST decreased significantly as the tumor histologic score increased. For dogs in the amputation-only group, MST decreased as body weight increased. Conclusions and Clinical Relevance-For the small-breed dogs with appendicular osteosarcoma of the present study, tumor histologic grade and mitotic index were subjectively lower and MST following amputation of the affected limb without adjuvant chemotherapy was longer, compared with those for similarly affected larger dogs. Results indicated no significant advantage in MST for dogs that underwent curative-intent treatment versus dogs that underwent amputation only, and further investigation of the importance of adjuvant chemotherapy is warranted.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalJournal of the American Veterinary Medical Association
Issue number2
StatePublished - Jul 15 2014

ASJC Scopus subject areas

  • veterinary(all)


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