Anxiety type modulates immediate versus delayed engagement of attention-related brain regions

Jeffrey M. Spielberg, Angeline A. De Leon, Keith Bredemeier, Wendy Heller, Anna S. Engels, Stacie L. Warren, Laura D. Crocker, Bradley P. Sutton, Gregory A. Miller

Research output: Contribution to journalArticle

Abstract

Background: Habituation of the fear response, critical for the treatment of anxiety, is inconsistently observed during exposure to threatening stimuli. One potential explanation for this inconsistency is differential attentional engagement with negatively valenced stimuli as a function of anxiety type. Methods: The present study tested this hypothesis by examining patterns of neural habituation associated with anxious arousal, characterized by panic symptoms and immediate engagement with negatively valenced stimuli, versus anxious apprehension, characterized by engagement in worry to distract from negatively valenced stimuli. Results: As predicted, the two anxiety types evidenced distinct patterns of attentional engagement. Anxious arousal was associated with immediate activation in attention-related brain regions that habituated over time, whereas anxious apprehension was associated with delayed activation in attention-related brain regions that occurred only after habituation in a worry-related brain region. Conclusions: Results further elucidate mechanisms involved in attention to negatively valenced stimuli and indicate that anxiety is a heterogeneous construct with regard to attention to such stimuli.

Original languageEnglish (US)
Pages (from-to)532-551
Number of pages20
JournalBrain and Behavior
Volume3
Issue number5
DOIs
StatePublished - Sep 1 2013

Keywords

  • Anxiety
  • Anxious apprehension
  • Anxious arousal
  • Attention
  • fMRI
  • Habituation
  • Negative valence

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Spielberg, J. M., De Leon, A. A., Bredemeier, K., Heller, W., Engels, A. S., Warren, S. L., Crocker, L. D., Sutton, B. P., & Miller, G. A. (2013). Anxiety type modulates immediate versus delayed engagement of attention-related brain regions. Brain and Behavior, 3(5), 532-551. https://doi.org/10.1002/brb3.157