GABA A receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA A receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA A receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA A receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'.
- GABA receptor
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience