Anxiety and depression: Mouse genetics and pharmacological approaches to the role of GABA A receptor subtypes

Kiersten S. Smith, Uwe Rudolph

Research output: Contribution to journalArticlepeer-review

Abstract

GABA A receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA A receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA A receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA A receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'.

Original languageEnglish (US)
Pages (from-to)54-62
Number of pages9
JournalNeuropharmacology
Volume62
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Anxiety
  • Benzodiazepines
  • Depression
  • Development
  • GABA receptor

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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