Anxiety and depression: Mouse genetics and pharmacological approaches to the role of GABA A receptor subtypes

Kiersten S. Smith; Uwe Rudolph

doi:10.1016/j.neuropharm.2011.07.026

Anxiety and depression: Mouse genetics and pharmacological approaches to the role of GABA _A receptor subtypes

Kiersten S. Smith, Uwe Rudolph

Research output: Contribution to journal › Article › peer-review

Abstract

GABA _A receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA _A receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA _A receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA _A receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'.

Original language	English (US)
Pages (from-to)	54-62
Number of pages	9
Journal	Neuropharmacology
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/j.neuropharm.2011.07.026
State	Published - Jan 2012
Externally published	Yes

Keywords

Anxiety
Benzodiazepines
Depression
Development
GABA receptor

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

Online availability

10.1016/j.neuropharm.2011.07.026

Library availability

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Cite this

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abstract = "GABA A receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA A receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA A receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA A receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'.",

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