TY - PAT
T1 - Antithrombotic compounds, methods and uses thereof
AU - Morrissey, James H
AU - Kizhakkedathu, Jayachandran N
AU - Smith, Stephanie A
AU - Shenoi, Rajesh
AU - Kalathottukaren, Manu T
AU - Travers, Richard J
N1 - STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with government support under contract numbers R01 HL047014, awarded by the National Institutes of Health, and AHA Predoctoral Fellowship 13PRE14550007, awarded by the American Heart Association. The government has certain rights in the invention.
PY - 2019/2/12
Y1 - 2019/2/12
N2 - Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deep-vein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
AB - Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deep-vein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
M3 - Patent
M1 - 10202507
Y2 - 2015/05/29
ER -