Antiproliferative hybrid analogs of the hormone 1α,25-dihydroxyvitamin D₃: Design, synthesis, and preliminary biological evaluation

Keyphrases

• Biological Evaluation 100%
• Calcitriol 100%
• Antiproliferative Activity 100%
• 1,25-dihydroxyvitamin D3 100%
• Hybrid Analog 100%
• Bromo 50%
• Phosphine Oxide 50%
• Dichlorides 50%
• Physiologically Relevant 50%
• Zinc 50%
• Nanomolar Concentrations 50%
• Keratinocytes 50%
• Tert 50%
• Allyl 50%
• Conjugate Base 50%
• Highly Stereoselective 50%
• Highly Regioselective 50%
• A-ring 50%
• 1-butene 50%
• Diels-Alder Cycloaddition 50%
• Terminal Alkenes 50%
• 2-Pyrone 50%
• Keto Group 50%
• β-diketone 50%

Chemistry

• Antiproliferative 100%
• Calcitriol 100%
• Base 50%
• Phosphine Oxide 50%
• Alkene 50%
• Butene 50%
• Pyrone 50%
• Diketone 50%
• Diels-Alder Cycloaddition 50%
• Zinc Dichloride 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Calcitriol 100%
• Base 25%
• Pyrone Derivative 25%
• Alkene 25%
• Alder 25%
• Diketone 25%