Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Mary H. Grace, Carmen Lategan, Flaubert Mbeunkui, Rocky Graziose, Peter J. Smith, Ilya Raskin, Mary Ann Lila

Research output: Contribution to journalArticlepeer-review

Abstract

The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

Original languageEnglish (US)
Pages (from-to)1869-1872
Number of pages4
JournalNatural Product Communications
Volume5
Issue number12
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Antimalarial
  • Antiplasmodial
  • Canella winterana
  • Cytotoxicity
  • Drimane sesquiterpenes

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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