Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Mary H. Grace; Carmen Lategan; Flaubert Mbeunkui; Rocky Graziose; Peter J. Smith; Ilya Raskin; Mary Ann Lila

doi:10.1177/1934578x1000501205

Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Mary H. Grace, Carmen Lategan, Flaubert Mbeunkui, Rocky Graziose, Peter J. Smith, Ilya Raskin, Mary Ann Lila

Research output: Contribution to journal › Article › peer-review

Abstract

The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC₅₀ 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC₅₀-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC₅₀-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

Original language	English (US)
Pages (from-to)	1869-1872
Number of pages	4
Journal	Natural Product Communications
Volume	5
Issue number	12
DOIs	https://doi.org/10.1177/1934578x1000501205
State	Published - 2010
Externally published	Yes

Keywords

Antimalarial
Antiplasmodial
Canella winterana
Cytotoxicity
Drimane sesquiterpenes

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1000501205

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title = "Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana",

abstract = "The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.",

keywords = "Antimalarial, Antiplasmodial, Canella winterana, Cytotoxicity, Drimane sesquiterpenes",

author = "Grace, {Mary H.} and Carmen Lategan and Flaubert Mbeunkui and Rocky Graziose and Smith, {Peter J.} and Ilya Raskin and Lila, {Mary Ann}",

year = "2010",

doi = "10.1177/1934578x1000501205",

language = "English (US)",

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pages = "1869--1872",

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T1 - Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

AU - Grace, Mary H.

AU - Lategan, Carmen

AU - Mbeunkui, Flaubert

AU - Graziose, Rocky

AU - Smith, Peter J.

AU - Raskin, Ilya

AU - Lila, Mary Ann

PY - 2010

Y1 - 2010

N2 - The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

AB - The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

KW - Antimalarial

KW - Antiplasmodial

KW - Canella winterana

KW - Cytotoxicity

KW - Drimane sesquiterpenes

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