Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Mary H. Grace; Carmen Lategan; Flaubert Mbeunkui; Rocky Graziose; Peter J. Smith; Ilya Raskin; Mary Ann Lila

Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Mary H. Grace, Carmen Lategan, Flaubert Mbeunkui, Rocky Graziose, Peter J. Smith, Ilya Raskin, Mary Ann Lila

Research output: Contribution to journal › Article

Abstract

The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC₅₀ 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC₅₀-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC₅₀-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

Original language	English (US)
Pages (from-to)	1869-1872
Number of pages	4
Journal	Natural Product Communications
Volume	5
Issue number	12
State	Published - Dec 1 2010
Externally published	Yes

Keywords

Antimalarial
Antiplasmodial
Canella winterana
Cytotoxicity
Drimane sesquiterpenes

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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Grace, M. H., Lategan, C., Mbeunkui, F., Graziose, R., Smith, P. J., Raskin, I., & Lila, M. A. (2010). Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana. Natural Product Communications, 5(12), 1869-1872.

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abstract = "The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.",

keywords = "Antimalarial, Antiplasmodial, Canella winterana, Cytotoxicity, Drimane sesquiterpenes",

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AU - Grace, Mary H.

AU - Lategan, Carmen

AU - Mbeunkui, Flaubert

AU - Graziose, Rocky

AU - Smith, Peter J.

AU - Raskin, Ilya

AU - Lila, Mary Ann

PY - 2010/12/1

Y1 - 2010/12/1

N2 - The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

AB - The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

KW - Antimalarial

KW - Antiplasmodial

KW - Canella winterana

KW - Cytotoxicity

KW - Drimane sesquiterpenes

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