TY - JOUR
T1 - Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana
AU - Grace, Mary H.
AU - Lategan, Carmen
AU - Mbeunkui, Flaubert
AU - Graziose, Rocky
AU - Smith, Peter J.
AU - Raskin, Ilya
AU - Lila, Mary Ann
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.
AB - The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.
KW - Antimalarial
KW - Antiplasmodial
KW - Canella winterana
KW - Cytotoxicity
KW - Drimane sesquiterpenes
UR - http://www.scopus.com/inward/record.url?scp=78751538177&partnerID=8YFLogxK
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U2 - 10.1177/1934578x1000501205
DO - 10.1177/1934578x1000501205
M3 - Article
C2 - 21299109
AN - SCOPUS:78751538177
VL - 5
SP - 1869
EP - 1872
JO - Natural Product Communications
JF - Natural Product Communications
SN - 1934-578X
IS - 12
ER -