Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Mary H. Grace, Carmen Lategan, Flaubert Mbeunkui, Rocky Graziose, Peter J. Smith, Ilya Raskin, Mary Ann Lila

Research output: Contribution to journalArticle

Abstract

The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-β-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 μg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 μg/mL, respectively. A structure-activity relationship is discussed.

Original languageEnglish (US)
Pages (from-to)1869-1872
Number of pages4
JournalNatural Product Communications
Volume5
Issue number12
StatePublished - Dec 1 2010
Externally publishedYes

Keywords

  • Antimalarial
  • Antiplasmodial
  • Canella winterana
  • Cytotoxicity
  • Drimane sesquiterpenes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Fingerprint Dive into the research topics of 'Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana'. Together they form a unique fingerprint.

  • Cite this

    Grace, M. H., Lategan, C., Mbeunkui, F., Graziose, R., Smith, P. J., Raskin, I., & Lila, M. A. (2010). Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana. Natural Product Communications, 5(12), 1869-1872.