Antioxidant effects of citrus flavonoid consumption

John R. Burgess, Juan E. Andrade

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Grapefruit juice is a rich source of nutrients and citrus flavonoids which are proposed to provide important health benefits. Many flavonoids are good antioxidants in vitro and this property is one that is hypothesized to mediate their biological effects in vivo. In two studies we tested the effects of citrus flavanones and grapefruit juice on lipid oxidation and the antioxidant defense system in vivo. The first tested the dose-response effect of naringenin consumption in rats adequate or deficient in vitamin E and selenium on growth and multiple measures of antioxidant defense, lipid oxidation and oxidative stress. The second was a human intervention trial of three months in duration testing the effects of regular consumption of grapefruit juice on antioxidant nutrient status and oxidative stress in young adult women. No evidence of antioxidant or pro-oxidant activity was observed, however, in rats inhibition of adipose accumulation was observed.

Original languageEnglish (US)
Title of host publicationPotential Health Benefits of Citrus
PublisherAmerican Chemical Society
Number of pages14
ISBN (Print)0841239576, 9780841239579
StatePublished - 2006
Externally publishedYes

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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