TY - JOUR
T1 - Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium
AU - Gichner, Tomáš
AU - Voutsinas, Gerassimos
AU - Patrineli, Alexandra
AU - Kappas, Andreas
AU - Plewa, Michael J.
N1 - Funding Information:
Dr. Gichner is indebted to the European Environmental Research Organization, The Netherlands, for supporting his work at the National Research Center 'Democritus', Athens, Greece. This research was funded, in part, by U.S.-Czech Science and Technology Program Grant 930-13 (T.G. and M.J.P.), a J.W. Fulbright Scholarship (M.J.P.) and by U.S. Air Force Office of Scientific Research Grant AFOSR-91-0432 and U.S. Environmental Protection Agency Grant R815008 (M.J.P.). We are indebted to Dr. Karel Angelis (Institute of Experimental Botany, Prague) for calculating the first-order rate constants for the MNNG half-lives. We appreciate the helpful discussions and manuscript editing by Ms Elizabeth Wagner.
PY - 1994/9/1
Y1 - 1994/9/1
N2 - The m-, o- and p-isomers of aminobenzoic acid (ABA) repressed the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. Their antimutagenic potency was in the order of o-ABA >m-ABA > p-ABA. The mechanism of this antimutagenicity is ascribed mainly to the decomposition of MNNG induced by the aminobenzoic acid isomers outside or within the bacterial cells. The inhibition of plant cell peroxidases and bacterial acetyltransferases that are required for the plant activation of 2-aminofluorene (2-AF) to mutagenic product(s) may participate in the repression of 2-AF mutagenesis by the aminobenzoic acids in S. typhimurium strain YG1024. The aminobenzoic acid isomers exhibited no inhibitory effects towards the direct-acting agent 2-acetoxy-2-acetylaminofluorene, the stable diacetylated metabolic product of 2-AF.
AB - The m-, o- and p-isomers of aminobenzoic acid (ABA) repressed the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. Their antimutagenic potency was in the order of o-ABA >m-ABA > p-ABA. The mechanism of this antimutagenicity is ascribed mainly to the decomposition of MNNG induced by the aminobenzoic acid isomers outside or within the bacterial cells. The inhibition of plant cell peroxidases and bacterial acetyltransferases that are required for the plant activation of 2-aminofluorene (2-AF) to mutagenic product(s) may participate in the repression of 2-AF mutagenesis by the aminobenzoic acids in S. typhimurium strain YG1024. The aminobenzoic acid isomers exhibited no inhibitory effects towards the direct-acting agent 2-acetoxy-2-acetylaminofluorene, the stable diacetylated metabolic product of 2-AF.
KW - 2-Acetoxy-2-acetylamino-fluorene
KW - 2-Aminofluorene
KW - Mechanisms of antimutagenicity
KW - N-Methyl-N′-nitro-N-nitrosoguanidine
KW - O-Acetyltransferases
KW - Peroxidases
KW - meta-
KW - ortho-
KW - para-Aminobenzoic acid
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U2 - 10.1016/0027-5107(94)90093-0
DO - 10.1016/0027-5107(94)90093-0
M3 - Article
C2 - 7520977
AN - SCOPUS:0027939720
VL - 309
SP - 201
EP - 210
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 2
ER -