Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium

Tomáš Gichner, Gerassimos Voutsinas, Alexandra Patrineli, Andreas Kappas, Michael J. Plewa

Research output: Contribution to journalArticle

Abstract

The m-, o- and p-isomers of aminobenzoic acid (ABA) repressed the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. Their antimutagenic potency was in the order of o-ABA >m-ABA > p-ABA. The mechanism of this antimutagenicity is ascribed mainly to the decomposition of MNNG induced by the aminobenzoic acid isomers outside or within the bacterial cells. The inhibition of plant cell peroxidases and bacterial acetyltransferases that are required for the plant activation of 2-aminofluorene (2-AF) to mutagenic product(s) may participate in the repression of 2-AF mutagenesis by the aminobenzoic acids in S. typhimurium strain YG1024. The aminobenzoic acid isomers exhibited no inhibitory effects towards the direct-acting agent 2-acetoxy-2-acetylaminofluorene, the stable diacetylated metabolic product of 2-AF.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalMutation Research Regular Papers
Volume309
Issue number2
DOIs
StatePublished - Sep 1 1994

Fingerprint

Aminobenzoates
Salmonella typhimurium
4-Aminobenzoic Acid
ortho-Aminobenzoates
Nitrosoguanidines
2-Acetylaminofluorene
Methylnitronitrosoguanidine
Peroxidases
Acetyltransferases
Plant Cells
Mutagenesis
2-aminofluorene

Keywords

  • 2-Acetoxy-2-acetylamino-fluorene
  • 2-Aminofluorene
  • Mechanisms of antimutagenicity
  • N-Methyl-N′-nitro-N-nitrosoguanidine
  • O-Acetyltransferases
  • Peroxidases
  • meta-
  • ortho-
  • para-Aminobenzoic acid

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium. / Gichner, Tomáš; Voutsinas, Gerassimos; Patrineli, Alexandra; Kappas, Andreas; Plewa, Michael J.

In: Mutation Research Regular Papers, Vol. 309, No. 2, 01.09.1994, p. 201-210.

Research output: Contribution to journalArticle

Gichner, T, Voutsinas, G, Patrineli, A, Kappas, A & Plewa, MJ 1994, 'Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium', Mutation Research Regular Papers, vol. 309, no. 2, pp. 201-210. https://doi.org/10.1016/0027-5107(94)90093-0
Gichner, Tomáš ; Voutsinas, Gerassimos ; Patrineli, Alexandra ; Kappas, Andreas ; Plewa, Michael J. / Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium. In: Mutation Research Regular Papers. 1994 ; Vol. 309, No. 2. pp. 201-210.
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