Polymers play important roles in the design of delivery nanocarriers for cancer therapies. Polymeric nanocarriers with anticancer drugs conjugated or encapsulated, also known as polymeric nanomedicines, form a variety of different architectures including polymer-drug conjugates, micelles, nanospheres, nanogels, vesicles, and dendrimers. This review focuses on the current state of the preclinical and clinical investigations of polymer-drug conjugates and polymeric micelles. Recent progress achieved in some promising fields, such as site-specific protein conjugation, pH-sensitive polymer-drug conjugates, polymer nanoparticles for targeted cancer therapy, stimuli-responsive polymeric micelles, polymeric vesicles, and dendrimer-based anticancer nanomedicines, will be highlighted.

Original languageEnglish (US)
Pages (from-to)345-381
Number of pages37
JournalPolymer Reviews
Issue number3
StatePublished - Jul 2007


  • Anticancer
  • Drug delivery
  • Nanomedicine
  • Polymer-drug conjugate
  • Polymeric micelle
  • Polymeric nanoparticle

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Biomedical Engineering
  • Electronic, Optical and Magnetic Materials
  • Renewable Energy, Sustainability and the Environment
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry


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