TY - JOUR
T1 - Anticancer polymeric nanomedicines
AU - Tong, Rong
AU - Cheng, Jianjun
N1 - Funding Information:
This work is supported by a start-up grant from the University of Illinois, by a seed grant from the Siteman Center for Cancer Nanotechnology Excellence (SCCNE, Washington University)-Center for Nanoscale Science and Technology (CNST, University of Illinois), and by a Prostate Cancer Foundation Competitive Award. RT acknowledges the support of a student fellowship from SCCNE-CNST.
PY - 2007/7
Y1 - 2007/7
N2 - Polymers play important roles in the design of delivery nanocarriers for cancer therapies. Polymeric nanocarriers with anticancer drugs conjugated or encapsulated, also known as polymeric nanomedicines, form a variety of different architectures including polymer-drug conjugates, micelles, nanospheres, nanogels, vesicles, and dendrimers. This review focuses on the current state of the preclinical and clinical investigations of polymer-drug conjugates and polymeric micelles. Recent progress achieved in some promising fields, such as site-specific protein conjugation, pH-sensitive polymer-drug conjugates, polymer nanoparticles for targeted cancer therapy, stimuli-responsive polymeric micelles, polymeric vesicles, and dendrimer-based anticancer nanomedicines, will be highlighted.
AB - Polymers play important roles in the design of delivery nanocarriers for cancer therapies. Polymeric nanocarriers with anticancer drugs conjugated or encapsulated, also known as polymeric nanomedicines, form a variety of different architectures including polymer-drug conjugates, micelles, nanospheres, nanogels, vesicles, and dendrimers. This review focuses on the current state of the preclinical and clinical investigations of polymer-drug conjugates and polymeric micelles. Recent progress achieved in some promising fields, such as site-specific protein conjugation, pH-sensitive polymer-drug conjugates, polymer nanoparticles for targeted cancer therapy, stimuli-responsive polymeric micelles, polymeric vesicles, and dendrimer-based anticancer nanomedicines, will be highlighted.
KW - Anticancer
KW - Drug delivery
KW - Nanomedicine
KW - Polymer-drug conjugate
KW - Polymeric micelle
KW - Polymeric nanoparticle
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U2 - 10.1080/15583720701455079
DO - 10.1080/15583720701455079
M3 - Article
AN - SCOPUS:34547797860
SN - 0022-2348
VL - 47
SP - 345
EP - 381
JO - Journal of Macromolecular Science, Part C
JF - Journal of Macromolecular Science, Part C
IS - 3
ER -