Abstract
We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1581-1585 |
| Number of pages | 5 |
| Journal | Polymer Chemistry |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 7 2014 |
ASJC Scopus subject areas
- Bioengineering
- Biochemistry
- Polymers and Plastics
- Organic Chemistry