Abstract
We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1581-1585 |
| Number of pages | 5 |
| Journal | Polymer Chemistry |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 7 2014 |
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ASJC Scopus subject areas
- Bioengineering
- Biochemistry
- Polymers and Plastics
- Organic Chemistry
Cite this
Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker. / Yin, Qian; Tong, Rong; Yin, Lichen; Fan, Timothy M.; Cheng, Jianjun.
In: Polymer Chemistry, Vol. 5, No. 5, 07.03.2014, p. 1581-1585.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker
AU - Yin, Qian
AU - Tong, Rong
AU - Yin, Lichen
AU - Fan, Timothy M.
AU - Cheng, Jianjun
PY - 2014/3/7
Y1 - 2014/3/7
N2 - We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
AB - We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
UR - http://www.scopus.com/inward/record.url?scp=84893438826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893438826&partnerID=8YFLogxK
U2 - 10.1039/c3py01245j
DO - 10.1039/c3py01245j
M3 - Article
AN - SCOPUS:84893438826
VL - 5
SP - 1581
EP - 1585
JO - Polymer Chemistry
JF - Polymer Chemistry
SN - 1759-9954
IS - 5
ER -