Abstract

We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

Original languageEnglish (US)
Pages (from-to)1581-1585
Number of pages5
JournalPolymer Chemistry
Volume5
Issue number5
DOIs
StatePublished - Mar 7 2014

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Nanoconjugates
Camptothecin
Lactic acid
Esters
Polymerization
Lewis Lung Carcinoma
Inbred C57BL Mouse
poly(lactide)
poly(lactic acid)
Therapeutics

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker. / Yin, Qian; Tong, Rong; Yin, Lichen; Fan, Timothy M.; Cheng, Jianjun.

In: Polymer Chemistry, Vol. 5, No. 5, 07.03.2014, p. 1581-1585.

Research output: Contribution to journalArticle

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