Abstract
We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
Original language | English (US) |
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Pages (from-to) | 1581-1585 |
Number of pages | 5 |
Journal | Polymer Chemistry |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - Mar 7 2014 |
ASJC Scopus subject areas
- Bioengineering
- Biochemistry
- Polymers and Plastics
- Organic Chemistry