Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Qian Yin; Rong Tong; Lichen Yin; Timothy M. Fan; Jianjun Cheng

doi:10.1039/c3py01245j

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Qian Yin, Rong Tong, Lichen Yin, Timothy M. Fan, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

Original language	English (US)
Pages (from-to)	1581-1585
Number of pages	5
Journal	Polymer Chemistry
Volume	5
Issue number	5
DOIs	https://doi.org/10.1039/c3py01245j
State	Published - Mar 7 2014

ASJC Scopus subject areas

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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10.1039/c3py01245j

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abstract = "We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.",

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AU - Yin, Qian

AU - Tong, Rong

AU - Yin, Lichen

AU - Fan, Timothy M.

AU - Cheng, Jianjun

PY - 2014/3/7

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N2 - We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

AB - We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.

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JF - Polymer Chemistry

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Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Abstract

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