Antibacterial properties of plasma from the prairie rattlesnake (Crotalus viridis).

Sarah J. Baker, Mark E. Merchant

Research output: Contribution to journalArticlepeer-review


The innate immune system functions to quickly respond to pathogens and is likely the primary line of defense for ectothermic vertebrates. Snake populations appear to be in widespread decline globally, but despite the threats from emerging pathogens, very little work has been conducted to characterize their basic immune function. We used a wide-ranging snake species, the Prairie Rattlesnake (Crotalus viridis), to measure effects of snake plasma on the growth of eight bacterial species. Additionally, we quantified bacterial killing ability and kinetics of the immune response. Our results show that Prairie Rattlesnakes have robust innate immune systems, and concentrations of 10% snake plasma inhibit growth of 6 of 8 bacteria tested. Undiluted snake plasma inhibited nearly all bacterial growth. The immune response was fairly rapid, inhibiting 73% of bacterial growth within 20 min of exposure. These results are encouraging for conservation of wild populations, as snakes appear to exhibit a strong innate immune response. However, further work needs to be directed toward the evaluation of immune system capabilities in individual populations of conservation concern, and against pathogens known to cause mortality in wild snakes.
Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalDevelopmental and Comparative Immunology
StatePublished - Jul 2018
Externally publishedYes


  • INHS
  • Antimicrobial
  • Serum complement
  • Bacteria
  • Innate immunity
  • Rattlesnake

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology


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