Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme A synthesis

Jacob Thomas, John E. Cronan

Research output: Contribution to journalArticlepeer-review

Abstract

Growth inhibition by the pantothenate analog N-pentylpantothenamide (N5-Pan) has been attributed to the accumulation of acyl carrier protein carrying a prosthetic group modified by incorporation of N5-Pan. This was attributed to an inability of the AcpH acyl carrier protein phosphodiesterase to cleave the N5-Pan-modified prosthetic group from the protein moiety. We report that AcpH readily removes the N5-Pan-modified prosthetic group both in vivo and in vitro and show that N5-Pan blocks coenzyme A synthesis.

Original languageEnglish (US)
Pages (from-to)1374-1377
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number3
DOIs
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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