Anti-Markovnikov Hydroamination of Homoallylic Amines

Seth C. Ensign, Evan P. Vanable, Gregory D. Kortman, Lee J. Weir, Kami L. Hull

Research output: Contribution to journalArticlepeer-review


The development of an anti-Markovnikov-selective hydroamination of unactivated alkenes is a significant challenge in organometallic chemistry. Herein, we present the rhodium-catalyzed anti-Markovnikov-selective hydroamination of homoallylic amines. The proximal Lewis basic amine serves to promote reactivity and enforce regioselectivity through the formation of the favored metallacycle, thus over-riding the inherent reactivity of the alkene. The scope of both the amine nucleophiles and homoallylic amines that participate in the reaction is demonstrated.

Original languageEnglish (US)
Pages (from-to)13748-13751
Number of pages4
JournalJournal of the American Chemical Society
Issue number43
StatePublished - Nov 4 2015

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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