Puntos de corte antropométricos para identificar las características de la lipodistrofia en personas que viven con vih/sida: Un estudio observacional

Translated title of the contribution: Anthropometric cutoff points to identify lipodystrophy characteristics in people living with HIV/AIDS: An observational study

André Pereira Dos Santos, Dalmo Roberto Lopes Machado, Andiara Schwingel, Wojtek Jan Chodzko-Zajko, Thiago Cândido Alves, Pedro Pugliesi Abdalla, Ana Claudia Rossini Venturini, Valdes Roberto Bollela, Anderson Marliere Navarro

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: currently, there is no consensus regarding accurate and low-cost methods for diagnosing lipodystrophy in people living with HIV/ AIDS (PLWHA). The aim of this study was to propose anthropometric cutoff points for the diagnosis of lipodystrophy among PLWHA. Methods: we included 106 PLWHA (men = 65, women = 41) who are under antiretroviral therapy and have been clinically classified into either a “lipodystrophy” or “non-lipodystrophy” group. Anthropometric measurements included 19 regions of body perimeters and 6 skinfold thickness measures. The Youden index was used to establish anthropometric cutoff points for the diagnosis of lipodystrophy, using the mean values of the anthropometric data (referred to as “original”) along with the “Z index” (ZI) values, which were adjusted by the “Phantom Strategy.” The cutoff points were proposed when “original” anthropometric measurements and ZI values had a statistical significance of p < 0.01 and an area under the curve (AUC) higher than 70%. The size effect was assessed to verify the influence of lipodystrophy on each anthropometric measure. Results: our data analysis proposes sex-specific cutoff points for the diagnosis of lipodystrophy in PLWHA – 17 points using the “original” anthropometric measurements, and 20 using the ZI values (average effect size between 1.0 and 1.1, and AUC = 76.7% and 78%). Conclusions: our study proposes accurate cutoff points for the diagnosis of lipodystrophy using “original” anthropometric measurements and ZI values adjusted by the “Phantom Strategy.” Our findings support the use of anthropometric measurements as a simplified method for diagnosing lipodystrophy and monitoring body composition alterations in people living with HIV/AIDS.

Translated title of the contributionAnthropometric cutoff points to identify lipodystrophy characteristics in people living with HIV/AIDS: An observational study
Original languageSpanish
Pages (from-to)1315-1323
Number of pages9
JournalNutricion Hospitalaria
Volume36
Issue number6
DOIs
StatePublished - 2019

Keywords

  • Anthropometry
  • Body composition
  • HIV

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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