@article{edd306b5df51403483f52916739f795c,
title = "Anterior pituitary transcriptome suggests differences in ACTH release in tame and aggressive foxes",
abstract = "Domesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as {"}domestication syndrome.{"} These changes may include a reduction in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and specifically reduced adrenocorticotropic hormone release from the anterior pituitary. To investigate the biological mechanisms targeted during domestication, we investigated gene expression in the pituitaries of experimentally domesticated foxes (Vulpes vulpes). RNA was sequenced from the anterior pituitary of six foxes selectively bred for tameness ({"}tame foxes{"}) and six foxes selectively bred for aggression ({"}aggressive foxes{"}). Expression, splicing, and network differences identified between the two lines indicated the importance of genes related to regulation of exocytosis, specifically mediated by cAMP, organization of pseudopodia, and cell motility. These findings provide new insights into biological mechanisms that may have been targeted when these lines of foxes were selected for behavior and suggest new directions for research into HPA axis regulation and the biological underpinnings of domestication.",
keywords = "Domestication, Hypothalamicpituitaryadrenal axis, RNA-seq pituitary, Vulpes vulpes",
author = "Hekman, {Jessica P.} and Johnson, {Jennifer L.} and Whitney Edwards and Vladimirova, {Anastasiya V.} and Gulevich, {Rimma G.} and Ford, {Alexandra L.} and Kharlamova, {Anastasiya V.} and Yury Herbeck and Acland, {Gregory M.} and Raetzman, {Lori T.} and Trut, {Lyudmila N.} and Kukekova, {Anna V.}",
note = "Funding Information: We thank Irina V. Pivovarova, Tatyana I. Semenova, Eugene A. Martinov, and all the animal keepers at the Institute of Cytology and Genetics (ICG) experimental farm for research assistance. We are grateful for the insights of Andrew G. Clark, Xu Wang, Lisa Stubbs, Michael Saul, Jonathan E. Beever, and Waqar Yarif. This project was supported by National Institutes of Health (grant number GM120782), the United States Department of Agriculture Federal Hatch Project (grant number 538922), a Campus Research Board grant from the University of Illinois at Urbana-Champaign, the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (grant number 0324-2018-0016; animal maintenance), the Russian Scientific Foundation (grant number 16-14-10216; data collection and analysis), the Jonathan Baldwin Turner Scholarship Program (to J.P.H.), and personal support from Temple Grandin (to J.P.H.). Funding Information: We thank Irina V. Pivovarova, Tatyana I. Semenova, Eugene A. Martinov, and all the animal keepers at the Institute of Cytology and Genetics (ICG) experimental farm for research assistance. We are grateful for the insights of Andrew G. Clark, Xu Wang, Lisa Stubbs, Michael Saul, Jonathan E. Beever, and Waqar Yarif. This project was supported by National Institutes of Health (grant number GM120782), the United States Department of Agriculture Federal Hatch Project (grant number 538922), a Campus Research Board grant from the University of Illinois at Urbana-Champaign, the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (grant number 0324-2018-0016; animal maintenance), the Russian Scientific Foundation (grant number 16-14-10216; data collection and analysis), the Jonathan Baldwin Turner Scholarship Program (to J. P. H. ), and personal support from Temple Grandin (to J. P. H. ). Publisher Copyright: {\textcopyright} 2018 Hekman et al.",
year = "2018",
month = mar,
day = "1",
doi = "10.1534/g3.117.300508",
language = "English (US)",
volume = "8",
pages = "859--873",
journal = "G3: Genes, Genomes, Genetics",
issn = "2160-1836",
publisher = "Genetics Society of America",
number = "3",
}