Anomalous Gene Expression in Alzheimer Disease: Cause or Effect

D. R.C. Mclachlan; W. J. Lukiw; C. Mizzen; M. E. Percy; M. J. Somerville; M. K. Sutherland; L. Wong

doi:10.1017/S0317167100032571

Anomalous Gene Expression in Alzheimer Disease: Cause or Effect

D. R.C. Mclachlan, W. J. Lukiw, C. Mizzen, M. E. Percy, M. J. Somerville, M. K. Sutherland, L. Wong

Research output: Contribution to journal › Article › peer-review

Abstract

Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.

Original language	English (US)
Pages (from-to)	414-418
Number of pages	5
Journal	Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Volume	18
Issue number	S3
DOIs	https://doi.org/10.1017/S0317167100032571
State	Published - Aug 1991
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1017/S0317167100032571

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title = "Anomalous Gene Expression in Alzheimer Disease: Cause or Effect",

abstract = "Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.",

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AU - Percy, M. E.

AU - Somerville, M. J.

AU - Sutherland, M. K.

AU - Wong, L.

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AB - Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.

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Anomalous Gene Expression in Alzheimer Disease: Cause or Effect

Abstract

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