Anomalous Gene Expression in Alzheimer Disease: Cause or Effect

D. R.C. Mclachlan, W. J. Lukiw, C. Mizzen, M. E. Percy, M. J. Somerville, M. K. Sutherland, L. Wong

Research output: Contribution to journalArticlepeer-review


Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.

Original languageEnglish (US)
Pages (from-to)414-418
Number of pages5
JournalCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Issue numberS3
StatePublished - Aug 1991
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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