Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.
|Original language||English (US)|
|Number of pages||5|
|Journal||Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques|
|State||Published - Aug 1991|
ASJC Scopus subject areas
- Clinical Neurology