Abstract

Appendicular osteosarcoma (OS) is a primary mesenchymal tumor arising from malignantly transformed osteoblasts. In people, OS is the most common nonhematopoietic, primary skeletal neoplasm diagnosed in adolescents and is the second leading cause of cancer-related fatalities within this age group. Despite aggressive therapeutic management, including limb-sparing surgeries and dose-intense systemic chemotherapies, 30-40% of patients will experience progressive metastatic disease within 5 years of diagnosis. In order to reduce the fatality rate associated with recurrent or metastatic OS, a more thorough understanding of OS pathogenesis and biology is required. Towards this pursuit, comparative animal models of OS have been developed and are actively being studied to expand our fundamental understanding of OS. It is anticipated that specific animal models of OS, which most accurately recapitulate the natural disease process in people, will be most useful for advancing our understanding of OS biology, and will facilitate the discovery of disease pathogenesis and the identification of novel therapeutic strategies for managing this lethal metastatic bone sarcoma.

Original languageEnglish (US)
Pages (from-to)1327-1338
Number of pages12
JournalExpert Review of Anticancer Therapy
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2010

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Osteosarcoma
Animal Models
Neoplasms
Osteoblasts
Sarcoma
Extremities
Age Groups
Bone and Bones
Drug Therapy
Therapeutics

Keywords

  • comparative oncology
  • murine model
  • primary bone sarcoma
  • spontaneous dog model
  • translational investigations

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

Animal models of osteosarcoma. / Fan, Timothy M.

In: Expert Review of Anticancer Therapy, Vol. 10, No. 8, 01.08.2010, p. 1327-1338.

Research output: Contribution to journalReview article

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abstract = "Appendicular osteosarcoma (OS) is a primary mesenchymal tumor arising from malignantly transformed osteoblasts. In people, OS is the most common nonhematopoietic, primary skeletal neoplasm diagnosed in adolescents and is the second leading cause of cancer-related fatalities within this age group. Despite aggressive therapeutic management, including limb-sparing surgeries and dose-intense systemic chemotherapies, 30-40{\%} of patients will experience progressive metastatic disease within 5 years of diagnosis. In order to reduce the fatality rate associated with recurrent or metastatic OS, a more thorough understanding of OS pathogenesis and biology is required. Towards this pursuit, comparative animal models of OS have been developed and are actively being studied to expand our fundamental understanding of OS. It is anticipated that specific animal models of OS, which most accurately recapitulate the natural disease process in people, will be most useful for advancing our understanding of OS biology, and will facilitate the discovery of disease pathogenesis and the identification of novel therapeutic strategies for managing this lethal metastatic bone sarcoma.",
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