Abstract

The incidence of chronic diseases is increasing, despite advances in clinical medicine. Human diseases are often difficult to decipher because of the complexity of genetics and lifestyles. As such, appropriate biomedical models are essential, since most medical knowledge, treatment regimes, and the development of medical devices that have contributed to clinical advancement are based on robust animal models. Animal models are essential tools for studying gene-gene interactions, gene-environment effects, and for preclinical testing of therapeutic interventions. Given that mice, the most common animal model, frequently do not faithfully recapitulate human diseases, pigs and other large mammals, such as the dog, will continue to serve as important biomedical models. This review discusses animal models used for understanding human diseases and highlights the advantages and disadvantages for each.

Original languageEnglish (US)
Article number32
Pages (from-to)1-9
Number of pages9
JournalCAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources
Volume4
DOIs
StatePublished - Nov 19 2009

Fingerprint

chronic diseases
human diseases
cancer
Chronic Disease
Animal Models
animal models
Gene-Environment Interaction
neoplasms
animal
Neoplasms
medical equipment
gene interaction
gene
Clinical Medicine
lifestyle
Life Style
Mammals
medicine
Swine
genes

Keywords

  • Animal model
  • Biotechnology
  • Chronic disease
  • Transgenic animal model

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Nature and Landscape Conservation
  • veterinary(all)

Cite this

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abstract = "The incidence of chronic diseases is increasing, despite advances in clinical medicine. Human diseases are often difficult to decipher because of the complexity of genetics and lifestyles. As such, appropriate biomedical models are essential, since most medical knowledge, treatment regimes, and the development of medical devices that have contributed to clinical advancement are based on robust animal models. Animal models are essential tools for studying gene-gene interactions, gene-environment effects, and for preclinical testing of therapeutic interventions. Given that mice, the most common animal model, frequently do not faithfully recapitulate human diseases, pigs and other large mammals, such as the dog, will continue to serve as important biomedical models. This review discusses animal models used for understanding human diseases and highlights the advantages and disadvantages for each.",
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