Abstract
The incidence of chronic diseases is increasing, despite advances in clinical medicine. Human diseases are often difficult to decipher because of the complexity of genetics and lifestyles. As such, appropriate biomedical models are essential, since most medical knowledge, treatment regimes, and the development of medical devices that have contributed to clinical advancement are based on robust animal models. Animal models are essential tools for studying gene-gene interactions, gene-environment effects, and for preclinical testing of therapeutic interventions. Given that mice, the most common animal model, frequently do not faithfully recapitulate human diseases, pigs and other large mammals, such as the dog, will continue to serve as important biomedical models. This review discusses animal models used for understanding human diseases and highlights the advantages and disadvantages for each.
| Original language | English (US) |
|---|---|
| Article number | 32 |
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources |
| Volume | 4 |
| DOIs | |
| State | Published - Nov 19 2009 |
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Keywords
- Animal model
- Biotechnology
- Chronic disease
- Transgenic animal model
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Nature and Landscape Conservation
- veterinary(all)
Cite this
Animal models for elucidating human disease : Confronting cancer and other chronic diseases. / Kuzmuk, Kristy N.; Schook, Lawrence B.
In: CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, Vol. 4, 32, 19.11.2009, p. 1-9.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Animal models for elucidating human disease
T2 - Confronting cancer and other chronic diseases
AU - Kuzmuk, Kristy N.
AU - Schook, Lawrence B.
PY - 2009/11/19
Y1 - 2009/11/19
N2 - The incidence of chronic diseases is increasing, despite advances in clinical medicine. Human diseases are often difficult to decipher because of the complexity of genetics and lifestyles. As such, appropriate biomedical models are essential, since most medical knowledge, treatment regimes, and the development of medical devices that have contributed to clinical advancement are based on robust animal models. Animal models are essential tools for studying gene-gene interactions, gene-environment effects, and for preclinical testing of therapeutic interventions. Given that mice, the most common animal model, frequently do not faithfully recapitulate human diseases, pigs and other large mammals, such as the dog, will continue to serve as important biomedical models. This review discusses animal models used for understanding human diseases and highlights the advantages and disadvantages for each.
AB - The incidence of chronic diseases is increasing, despite advances in clinical medicine. Human diseases are often difficult to decipher because of the complexity of genetics and lifestyles. As such, appropriate biomedical models are essential, since most medical knowledge, treatment regimes, and the development of medical devices that have contributed to clinical advancement are based on robust animal models. Animal models are essential tools for studying gene-gene interactions, gene-environment effects, and for preclinical testing of therapeutic interventions. Given that mice, the most common animal model, frequently do not faithfully recapitulate human diseases, pigs and other large mammals, such as the dog, will continue to serve as important biomedical models. This review discusses animal models used for understanding human diseases and highlights the advantages and disadvantages for each.
KW - Animal model
KW - Biotechnology
KW - Chronic disease
KW - Transgenic animal model
UR - http://www.scopus.com/inward/record.url?scp=70449499906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449499906&partnerID=8YFLogxK
U2 - 10.1079/PAVSNNR20094032
DO - 10.1079/PAVSNNR20094032
M3 - Review article
AN - SCOPUS:70449499906
VL - 4
SP - 1
EP - 9
JO - CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources
JF - CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources
SN - 1749-8848
M1 - 32
ER -