Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women

Steve D. McCole, Michael D. Brown, Geoffrey E. Moore, Robert E. Ferrell, Kenneth R. Wilund, Andrea Huberty, Larry W. Douglass, James M. Hagberg

Research output: Contribution to journalArticle

Abstract

We sought to determine whether the M235T angiotensinogen (AGT) polymorphism, either interacting with habitual physical activity (PA) levels or independently, was associated with cardiovascular (CV) hemodynamics during maximal and submaximal exercise. Sixty-one healthy postmenopausal women (16 sedentary, 21 physically active, and 24 endurance athletes) had heart rate (HR), blood pressure (BP), cardiac output, stroke volume (SV), total peripheral resistance (TPR), and arteriovenous O2 difference (a-vDo2) assessed during 40, 60, 80, and ∼100% of Vo2 max treadmill exercise. Vo2 max did not differ among AGT genotype groups; however, maximal HR was 14 beats/min higher in AGT TT than MM genotype women (P < 0.05). AGT TT genotype women also had 19 beats/min higher HR during ∼100% Vo2 max exercise than AGT MM genotype women (P = 0.008). AGT genotype also interacted with habitual PA levels to associate with systolic BP and a-vDo2 during ∼100% Vo2 max exercise (both P < 0.01). AGT TT genotype women had 11 beats/min higher HR during submaximal exercise than MM genotype women (P < 0.05). AGT genotype interacted with habitual PA levels to associate with systolic BP during submaximal exercise (P = 0.009). AGT genotype, independently or interacting with habitual PA levels, did not associate significantly with diastolic BP, cardiac output, SV, or TPR during maximal or submaximal exercise. Thus this common genetic variant in the renin-angiotensin system appears to associate, both interactively with habitual PA levels and independently, with HR, systolic BP, and a-vDo2 responses to maximal and submaximal exercise in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalPhysiological genomics
Volume2002
Issue number10
DOIs
StatePublished - Oct 2002
Externally publishedYes

Keywords

  • Blood pressure
  • Cardiac output
  • Genetics
  • Heart rate
  • Stroke volume

ASJC Scopus subject areas

  • Physiology
  • Genetics

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    McCole, S. D., Brown, M. D., Moore, G. E., Ferrell, R. E., Wilund, K. R., Huberty, A., Douglass, L. W., & Hagberg, J. M. (2002). Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women. Physiological genomics, 2002(10), 63-69. https://doi.org/10.1152/physiolgenomics.00106.2001