Angiogenic biomaterials to promote therapeutic regeneration and investigate disease progression

Research output: Contribution to journalReview articlepeer-review

Abstract

The vasculature is a key component of the tissue microenvironment. Traditionally known for its role in providing nutrients and oxygen to surrounding cells, the vasculature is now also acknowledged to provide signaling cues that influence biological outcomes in regeneration and disease. These cues come from the cells that comprise vasculature, as well as the dynamic biophysical and biochemical properties of the surrounding extracellular matrix that accompany vascular development and remodeling. In this review, we illustrate the larger role of the vasculature in the context of regenerative biology and cancer progression. We describe cellular, biophysical, biochemical, and metabolic components of vascularized microenvironments. Moreover, we provide an overview of multidimensional angiogenic biomaterials that have been developed to promote therapeutic vascularization and regeneration, as well as to mimic elements of vascularized microenvironments as a means to uncover mechanisms by which vasculature influences cancer progression and therapy.

Original languageEnglish (US)
Article number120207
JournalBiomaterials
Volume255
DOIs
StatePublished - Oct 2020

Keywords

  • Angiocrine
  • Angiogenesis
  • Biomaterials
  • Cancer
  • Hydrogels
  • Microenvironment
  • Regeneration
  • Stem cell
  • Vascularization

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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