Abstract
A victory in the pocket: An international team of chemists and biophysicists have resolved the long-standing question of the structure of the active site of the [FeFe] hydrogenases by assembling the active enzyme with a version of the active site synthesized in vitro (see scheme; HydF is a scaffold protein, HydA1 is a natural hydrogenase). The protein incorporating the diiron complex 2 showed similar activity to that of the natural enzyme.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13518-13520 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 51 |
| DOIs | |
| State | Published - Dec 16 2013 |
Keywords
- cofactors
- enzymology
- hydrogen
- hydrogenases
- iron
ASJC Scopus subject areas
- General Chemistry
- Catalysis
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