And the winner is⋯azadithiolate: An amine proton relay in the [FeFe] hydrogenases

David Schilter; Thomas B. Rauchfuss

doi:10.1002/anie.201307132

And the winner is⋯azadithiolate: An amine proton relay in the [FeFe] hydrogenases

David Schilter, Thomas B. Rauchfuss

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A victory in the pocket: An international team of chemists and biophysicists have resolved the long-standing question of the structure of the active site of the [FeFe] hydrogenases by assembling the active enzyme with a version of the active site synthesized in vitro (see scheme; HydF is a scaffold protein, HydA1 is a natural hydrogenase). The protein incorporating the diiron complex 2 showed similar activity to that of the natural enzyme.

Original language	English (US)
Pages (from-to)	13518-13520
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	51
DOIs	https://doi.org/10.1002/anie.201307132
State	Published - Dec 16 2013

Keywords

cofactors
enzymology
hydrogen
hydrogenases
iron

ASJC Scopus subject areas

General Chemistry
Catalysis

Online availability

10.1002/anie.201307132

Library availability

Discover UIUC Full Text

Cite this

@article{afd53e10e4f74eb5892b06198fa6d264,

title = "And the winner is⋯azadithiolate: An amine proton relay in the [FeFe] hydrogenases",

abstract = "A victory in the pocket: An international team of chemists and biophysicists have resolved the long-standing question of the structure of the active site of the [FeFe] hydrogenases by assembling the active enzyme with a version of the active site synthesized in vitro (see scheme; HydF is a scaffold protein, HydA1 is a natural hydrogenase). The protein incorporating the diiron complex 2 showed similar activity to that of the natural enzyme.",

keywords = "cofactors, enzymology, hydrogen, hydrogenases, iron",

author = "David Schilter and Rauchfuss, {Thomas B.}",

year = "2013",

month = dec,

day = "16",

doi = "10.1002/anie.201307132",

language = "English (US)",

volume = "52",

pages = "13518--13520",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons, Ltd.",

number = "51",

}

TY - JOUR

T1 - And the winner is⋯azadithiolate

T2 - An amine proton relay in the [FeFe] hydrogenases

AU - Schilter, David

AU - Rauchfuss, Thomas B.

PY - 2013/12/16

Y1 - 2013/12/16

N2 - A victory in the pocket: An international team of chemists and biophysicists have resolved the long-standing question of the structure of the active site of the [FeFe] hydrogenases by assembling the active enzyme with a version of the active site synthesized in vitro (see scheme; HydF is a scaffold protein, HydA1 is a natural hydrogenase). The protein incorporating the diiron complex 2 showed similar activity to that of the natural enzyme.

AB - A victory in the pocket: An international team of chemists and biophysicists have resolved the long-standing question of the structure of the active site of the [FeFe] hydrogenases by assembling the active enzyme with a version of the active site synthesized in vitro (see scheme; HydF is a scaffold protein, HydA1 is a natural hydrogenase). The protein incorporating the diiron complex 2 showed similar activity to that of the natural enzyme.

KW - cofactors

KW - enzymology

KW - hydrogen

KW - hydrogenases

KW - iron

UR - http://www.scopus.com/inward/record.url?scp=84890444366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890444366&partnerID=8YFLogxK

U2 - 10.1002/anie.201307132

DO - 10.1002/anie.201307132

M3 - Article

C2 - 24307392

AN - SCOPUS:84890444366

SN - 1433-7851

VL - 52

SP - 13518

EP - 13520

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 51

ER -

And the winner is⋯azadithiolate: An amine proton relay in the [FeFe] hydrogenases

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this