And the winner is⋯azadithiolate: An amine proton relay in the [FeFe] hydrogenases

David Schilter, Thomas B. Rauchfuss

Research output: Contribution to journalArticlepeer-review

Abstract

A victory in the pocket: An international team of chemists and biophysicists have resolved the long-standing question of the structure of the active site of the [FeFe] hydrogenases by assembling the active enzyme with a version of the active site synthesized in vitro (see scheme; HydF is a scaffold protein, HydA1 is a natural hydrogenase). The protein incorporating the diiron complex 2 showed similar activity to that of the natural enzyme.

Original languageEnglish (US)
Pages (from-to)13518-13520
Number of pages3
JournalAngewandte Chemie - International Edition
Volume52
Issue number51
DOIs
StatePublished - Dec 16 2013

Keywords

  • cofactors
  • enzymology
  • hydrogen
  • hydrogenases
  • iron

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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