TY - JOUR
T1 - Ancient DNA suggests modern wolves trace their origin to a Late Pleistocene expansion from Beringia
AU - Loog, Liisa
AU - Thalmann, Olaf
AU - Sinding, Mikkel Holger S.
AU - Schuenemann, Verena J.
AU - Perri, Angela
AU - Germonpré, Mietje
AU - Bocherens, Herve
AU - Witt, Kelsey E.
AU - Samaniego Castruita, Jose A.
AU - Velasco, Marcela S.
AU - Lundstrøm, Inge K.C.
AU - Wales, Nathan
AU - Sonet, Gontran
AU - Frantz, Laurent
AU - Schroeder, Hannes
AU - Budd, Jane
AU - Jimenez, Elodie Laure
AU - Fedorov, Sergey
AU - Gasparyan, Boris
AU - Kandel, Andrew W.
AU - Lázničková-Galetová, Martina
AU - Napierala, Hannes
AU - Uerpmann, Hans Peter
AU - Nikolskiy, Pavel A.
AU - Pavlova, Elena Y.
AU - Pitulko, Vladimir V.
AU - Herzig, Karl Heinz
AU - Malhi, Ripan S.
AU - Willerslev, Eske
AU - Hansen, Anders J.
AU - Dobney, Keith
AU - Gilbert, M. Thomas P.
AU - Krause, Johannes
AU - Larson, Greger
AU - Eriksson, Anders
AU - Manica, Andrea
N1 - Funding Information:
We are grateful to Daniel Klingberg Johansson & Kristian Murphy Gregersen from the Natural History Museum of Denmark; Gabriella Hürlimann from the Zurich Zoo; Jane Hopper from the Howlett's & the Port Lympne Wild Animal Parks; Cyrintha Barwise-Joubert & Paul Vercammen from the Breeding Centre for Endangered Arabian Wildlife; Link Olson from the University of Alaska Museum of the North; Joseph Cook & Mariel Campbell from the Museum of Southwestern Biology; Lindsey Carmichael & David Coltman from the University of Alberta; North American Fur Auctions; Department of Environment Nunavut and Environment and Natural Resources Northwest Territories for DNA samples from the modern wolves. We are also grateful to the staff at the Danish National High-Throughput Sequencing Centre for technical assistance in the data generation; the Qimmeq project, funded by The Velux Foundations and Aage og Johanne Louis-Hansens Fond, for providing financial support for sequencing ancient Siberian wolf samples; the Rock Foundation (New York, USA) for supporting radiocarbon dating of ancient samples from the Yana site; to Stephan Nylinder from the Swedish Museum of Natural History for advice on phylogenetic analyses and Terry Brown from the University of Manchester for comments on the manuscript. L.L., K.D. and G.L. were supported by the Natural Environment Research Council, UK (grant numbers NE/K005243/1, NE/K003259/1); LL was also supported by the European Research Council grant (339941-ADAPT); A.M. and A.E. were supported by the European Research Council Consolidator grant (grant number 647787-LocalAdaptation); L.F. and G.L. were supported by the European Research Council grant (ERC-2013-StG 337574-UNDEAD); T.G. was supported by a European Research Council Consolidator grant (681396-Extinction Genomics) & Lundbeck Foundation grant (R52-5062); O.T. was supported by the National Science Center, Poland (2015/19/P/NZ7/03971), with funding from EU's Horizon 2020 programme under the Marie Skłodowska-Curie grant agreement (665778) and Synthesys Project (BETAF 3062); V.P., E.P. and P.N. were supported by the Russian Science Foundation grant (N16-18-10265 RNF); A.P. was supported by the Max Planck Society; M.L-G. was supported by a Czech Science Foundation grant (GAČR15-06446S).
Funding Information:
We are grateful to Daniel Klingberg Johansson & Kristian Murphy Gregersen from the Natural History Museum of Denmark; Gabriella Hürlimann from the Zurich Zoo; Jane Hopper from the Howlett's & the Port Lympne Wild Animal Parks; Cyrintha Barwise‐Joubert & Paul Vercammen from the Breeding Centre for Endangered Arabian Wildlife; Link Olson from the University of Alaska Museum of the North; Joseph Cook & Mariel Campbell from the Museum of Southwestern Biology; Lindsey Carmichael & David Coltman from the University of Alberta; North American Fur Auctions; Department of Environment Nunavut and Environment and Natural Resources Northwest Territories for DNA samples from the modern wolves. We are also grateful to the staff at the Danish National High‐Throughput Sequencing Centre for technical assistance in the data generation; the Qimmeq project, funded by The Velux Foundations and Aage og Johanne Louis‐Hansens Fond, for providing financial support for sequencing ancient Siberian wolf samples; the Rock Foundation (New York, USA) for supporting radiocarbon dating of ancient samples from the Yana site; to Stephan Nylinder from the Swedish Museum of Natural History for advice on phylogenetic analyses and Terry Brown from the University of Manchester for comments on the manuscript. L.L., K.D. and G.L. were supported by the Natural Environment Research Council, UK (grant numbers NE/K005243/1, NE/K003259/1); LL was also supported by the European Research Council grant (339941‐ADAPT); A.M. and A.E. were supported by the European Research Council Consolidator grant (grant number 647787‐LocalAdaptation); L.F. and G.L. were supported by the European Research Council grant (ERC‐2013‐StG 337574‐UNDEAD); T.G. was supported by a European Research Council Consolidator grant (681396‐Extinction Genomics) & Lundbeck Foundation grant (R52‐5062); O.T. was supported by the National Science Center, Poland (2015/19/P/NZ7/03971), with funding from EU's Horizon 2020 programme under the Marie Skłodowska‐Curie grant agreement (665778) and Synthesys Project (BETAF 3062); V.P., E.P. and P.N. were supported by the Russian Science Foundation grant (N16‐18‐10265 RNF); A.P. was supported by the Max Planck Society; M.L‐G. was supported by a Czech Science Foundation grant (GAČR15‐06446S).
Publisher Copyright:
© 2019 The Authors. Molecular Ecology published by John Wiley & Sons Ltd
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Grey wolves (Canis lupus) are one of the few large terrestrial carnivores that have maintained a wide geographical distribution across the Northern Hemisphere throughout the Pleistocene and Holocene. Recent genetic studies have suggested that, despite this continuous presence, major demographic changes occurred in wolf populations between the Late Pleistocene and early Holocene, and that extant wolves trace their ancestry to a single Late Pleistocene population. Both the geographical origin of this ancestral population and how it became widespread remain unknown. Here, we used a spatially and temporally explicit modelling framework to analyse a data set of 90 modern and 45 ancient mitochondrial wolf genomes from across the Northern Hemisphere, spanning the last 50,000 years. Our results suggest that contemporary wolf populations trace their ancestry to an expansion from Beringia at the end of the Last Glacial Maximum, and that this process was most likely driven by Late Pleistocene ecological fluctuations that occurred across the Northern Hemisphere. This study provides direct ancient genetic evidence that long-range migration has played an important role in the population history of a large carnivore, and provides insight into how wolves survived the wave of megafaunal extinctions at the end of the last glaciation. Moreover, because Late Pleistocene grey wolves were the likely source from which all modern dogs trace their origins, the demographic history described in this study has fundamental implications for understanding the geographical origin of the dog.
AB - Grey wolves (Canis lupus) are one of the few large terrestrial carnivores that have maintained a wide geographical distribution across the Northern Hemisphere throughout the Pleistocene and Holocene. Recent genetic studies have suggested that, despite this continuous presence, major demographic changes occurred in wolf populations between the Late Pleistocene and early Holocene, and that extant wolves trace their ancestry to a single Late Pleistocene population. Both the geographical origin of this ancestral population and how it became widespread remain unknown. Here, we used a spatially and temporally explicit modelling framework to analyse a data set of 90 modern and 45 ancient mitochondrial wolf genomes from across the Northern Hemisphere, spanning the last 50,000 years. Our results suggest that contemporary wolf populations trace their ancestry to an expansion from Beringia at the end of the Last Glacial Maximum, and that this process was most likely driven by Late Pleistocene ecological fluctuations that occurred across the Northern Hemisphere. This study provides direct ancient genetic evidence that long-range migration has played an important role in the population history of a large carnivore, and provides insight into how wolves survived the wave of megafaunal extinctions at the end of the last glaciation. Moreover, because Late Pleistocene grey wolves were the likely source from which all modern dogs trace their origins, the demographic history described in this study has fundamental implications for understanding the geographical origin of the dog.
KW - Approximate Bayesian Computation
KW - Pleistocene
KW - ancient DNA
KW - coalescent modelling
KW - megafauna
KW - population structure
KW - population turnover
KW - wolves
UR - http://www.scopus.com/inward/record.url?scp=85078272954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078272954&partnerID=8YFLogxK
U2 - 10.1111/mec.15329
DO - 10.1111/mec.15329
M3 - Article
C2 - 31840921
AN - SCOPUS:85078272954
SN - 0962-1083
VL - 29
SP - 1596
EP - 1610
JO - Molecular Ecology
JF - Molecular Ecology
IS - 9
ER -