Analysis of Two Quantitative Ultrasound Approaches

Pauline Muleki-Seya, Aiguo Han, Michael P. Andre, John W. Erdman, William D. O’Brien

Research output: Contribution to journalArticlepeer-review


There are two well-known ultrasonic approaches to extract sets of quantitative parameters: Lizzi–Feleppa (LF) parameters: slope, intercept, and midband; and quantitative ultrasound (QUS)–derived parameters: effective scatterer diameter (ESD) and effective acoustic concentration (EAC). In this study, the relation between the LF and QUS-derived parameters is studied theoretically and experimentally on ex vivo mouse livers. As expected from the theory, LF slope is correlated to ESD (R2 =1.00), and from experimental data, LF midband is correlated to EAC (R2 =0.76). However, LF intercept is not correlated to ESD (R2 =0.25) nor EAC (R2 =0.07). The unexpected correlation observed between LF slope and EAC (R2 =0.94) results likely from the high correlation between ESD and EAC due to the inversion process. For a liver fat percentage estimation, an important potential medical application, the parameters presenting the better correlation are EAC (R2 =0.78) and LF midband (R2 =0.70).

Original languageEnglish (US)
Pages (from-to)84-96
Number of pages13
JournalUltrasonic Imaging
Issue number2
StatePublished - Mar 1 2018


  • Lizzi–Feleppa parameters
  • QUS parameters
  • mouse livers
  • quantitative ultrasound technique

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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