Analysis of the spectrum in phase-contrast mammography

Adam M. Zysk, Luis D. Sisternes, Jovan G. Brankov, Qiaofeng Xu, Miles N. Wernick, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


It has been proposed that the sensitivity of breast lesion detection can be improved with phase-contrast mammographic imaging. The recently introduced clinical system by Konica-Minolta, for example, reportedly yields enhanced lesion detectability. We hypothesize that the use of an optimized x-ray spectrum will result in even better performance. To test this hypothesis, we have performed a study of several clinical spectra from Mo and W sources over a broad spectral range. In the study, we have incorporated established dose measurements from a simple breast phantom used in the digital mammography literature, which has been updated to incorporate breast density properties in addition to conventional attenuation information. Established phase-contrast imaging simulation techniques, which employed a Fresnel propagator, were used to generate edge-enhanced radiographs for analysis. In addition, detector sensitivity and tube loading parameters were incorporated into the analysis. The resulting mammography images were analyzed via measurement of object edge-enhanced contrast.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationPhysics of Medical Imaging
StatePublished - Jun 15 2009
Externally publishedYes
EventMedical Imaging 2009: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 9 2009Feb 12 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2009: Physics of Medical Imaging
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Mammography
  • Phase-contrast imaging
  • X-ray imaging

ASJC Scopus subject areas

  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Radiology Nuclear Medicine and imaging
  • Atomic and Molecular Physics, and Optics


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