Abstract
The genotoxicity of extracts of anaerobically digested sewage sludge to human cells was assessed by measuring the induction of sister chromatid exchanges in human peripheral lymphocytes with and without mammalian hepatic microsomal activation. A 2 hr exposure time with a total culture time of 76 hr was necessary to circumvent problems with cell cycle delays induced by the agents present in the extracts. With this modified procedure, the three extracts tested demonstrated a statistically significant increase in the number of sister chromatid exchanges/chromosome observed suggesting the presence of a genotoxic component in the sewage sludge.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-128 |
| Number of pages | 12 |
| Journal | Water, Air, and Soil Pollution |
| Volume | 42 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 1988 |
ASJC Scopus subject areas
- Environmental Engineering
- Environmental Chemistry
- Ecological Modeling
- Water Science and Technology
- Pollution