Analysis of monoclonal antibodies reactive with the porcine CD4 antigen

M. D. Pescovitz, B. Aasted, A. Canals, J. Dominguez, J. S. Vizcaino, R. Pospisil, I. Trebichavsky, H. Salmon, I. Valpotic, W. C. Davis, S. Arn, D. H. Sachs, J. K. Lunney, F. Zuckerman, E. Weiland, A. Saalmueller

Research output: Contribution to journalArticlepeer-review


As result of the First International Swine CD Workshop, four monoclonal antibodies (mAb) (#002, 054, 118, and 127) clustered closely to the internal standard anti-porcine CD4 mAb, 74-12-4. To further characterize the relationship between these mAb, they were used in flow cytometry to inhibit binding of 74-12-4 to porcine lymphocytes. mAb #002 (74-12-4) and #054 (PT90) completely inhibited, while mAb #127 (10.2H2) and #118 (b38c6) partially inhibited (57% and 77% respectively), the binding of 74-12-4. Furthermore, none of the mAbs bound to a 74-12-4 negative strain of pigs. We conclude that the four mAb bind to the same, or a closely related, epitope on porcine lymphocytes.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalVeterinary Immunology and Immunopathology
Issue number1-3
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)


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