Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

María Fernanda Zurita, Paúl A. Cárdenas, María Elena Sandoval, María Caridad Peña, Marco Fornasini, Nancy Flores, Marcia H. Monaco, Kirsten Berding, Sharon M. Donovan, Thomas Kuntz, Jack A. Gilbert, Manuel E. Baldeón

Research output: Contribution to journalArticle

Abstract

Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

Original languageEnglish (US)
JournalGut Microbes
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Ecuador
Nutritional Status
Case-Control Studies
Ruminococcus
Bacteroides
Thinness
Microbiota
Feeding Behavior
Developed Countries
Developing Countries
Gastrointestinal Microbiome
Autism Spectrum Disorder
Serum

Keywords

  • Autism spectrum disorder
  • behavior
  • Ecuador
  • immunity
  • microbiota
  • nutrition

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Zurita, M. F., Cárdenas, P. A., Sandoval, M. E., Peña, M. C., Fornasini, M., Flores, N., ... Baldeón, M. E. (Accepted/In press). Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador. Gut Microbes. https://doi.org/10.1080/19490976.2019.1662260

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder : a case-control study in Ecuador. / Zurita, María Fernanda; Cárdenas, Paúl A.; Sandoval, María Elena; Peña, María Caridad; Fornasini, Marco; Flores, Nancy; Monaco, Marcia H.; Berding, Kirsten; Donovan, Sharon M.; Kuntz, Thomas; Gilbert, Jack A.; Baldeón, Manuel E.

In: Gut Microbes, 01.01.2019.

Research output: Contribution to journalArticle

Zurita, MF, Cárdenas, PA, Sandoval, ME, Peña, MC, Fornasini, M, Flores, N, Monaco, MH, Berding, K, Donovan, SM, Kuntz, T, Gilbert, JA & Baldeón, ME 2019, 'Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador', Gut Microbes. https://doi.org/10.1080/19490976.2019.1662260
Zurita, María Fernanda ; Cárdenas, Paúl A. ; Sandoval, María Elena ; Peña, María Caridad ; Fornasini, Marco ; Flores, Nancy ; Monaco, Marcia H. ; Berding, Kirsten ; Donovan, Sharon M. ; Kuntz, Thomas ; Gilbert, Jack A. ; Baldeón, Manuel E. / Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder : a case-control study in Ecuador. In: Gut Microbes. 2019.
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