Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

María Fernanda Zurita; Paúl A. Cárdenas; María Elena Sandoval; María Caridad Peña; Marco Fornasini; Nancy Flores; Marcia H. Monaco; Kirsten Berding; Sharon M. Donovan; Thomas Kuntz; Jack A. Gilbert; Manuel E. Baldeón

doi:10.1080/19490976.2019.1662260

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

María Fernanda Zurita, Paúl A. Cárdenas, María Elena Sandoval, María Caridad Peña, Marco Fornasini, Nancy Flores, Marcia H. Monaco, Kirsten Berding, Sharon M. Donovan, Thomas Kuntz, Jack A. Gilbert, Manuel E. Baldeón

Research output: Contribution to journal › Article › peer-review

Abstract

Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

Original language	English (US)
Pages (from-to)	453-464
Number of pages	12
Journal	Gut Microbes
Volume	11
Issue number	3
DOIs	https://doi.org/10.1080/19490976.2019.1662260
State	Published - May 3 2020

Keywords

Autism spectrum disorder
Ecuador
behavior
immunity
microbiota
nutrition

ASJC Scopus subject areas

Microbiology
Gastroenterology
Microbiology (medical)
Infectious Diseases

Online availability

10.1080/19490976.2019.1662260

Library availability

Discover UIUC Full Text

Cite this

Zurita, M. F., Cárdenas, P. A., Sandoval, M. E., Peña, M. C., Fornasini, M., Flores, N., Monaco, M. H., Berding, K., Donovan, S. M., Kuntz, T., Gilbert, J. A., & Baldeón, M. E. (2020). Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador. Gut Microbes, 11(3), 453-464. https://doi.org/10.1080/19490976.2019.1662260

@article{ff20c61fbdb94175b3f848c9ecf5ff58,

title = "Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador",

abstract = "Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.",

keywords = "Autism spectrum disorder, Ecuador, behavior, immunity, microbiota, nutrition",

author = "Zurita, {Mar{\'i}a Fernanda} and C{\'a}rdenas, {Pa{\'u}l A.} and Sandoval, {Mar{\'i}a Elena} and Pe{\~n}a, {Mar{\'i}a Caridad} and Marco Fornasini and Nancy Flores and Monaco, {Marcia H.} and Kirsten Berding and Donovan, {Sharon M.} and Thomas Kuntz and Gilbert, {Jack A.} and Balde{\'o}n, {Manuel E.}",

note = "Funding Information: This work was supported by the Agricultural Research Division, Institute of Agriculture and Natural Resources [ILLU-698-912]. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Taylor & Francis Group, LLC.",

year = "2020",

month = may,

day = "3",

doi = "10.1080/19490976.2019.1662260",

language = "English (US)",

volume = "11",

pages = "453--464",

journal = "Gut Microbes",

issn = "1949-0976",

publisher = "Landes Bioscience",

number = "3",

}

TY - JOUR

T1 - Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder

T2 - a case-control study in Ecuador

AU - Zurita, María Fernanda

AU - Cárdenas, Paúl A.

AU - Sandoval, María Elena

AU - Peña, María Caridad

AU - Fornasini, Marco

AU - Flores, Nancy

AU - Monaco, Marcia H.

AU - Berding, Kirsten

AU - Donovan, Sharon M.

AU - Kuntz, Thomas

AU - Gilbert, Jack A.

AU - Baldeón, Manuel E.

N1 - Funding Information: This work was supported by the Agricultural Research Division, Institute of Agriculture and Natural Resources [ILLU-698-912]. Publisher Copyright: © 2019, © 2019 Taylor & Francis Group, LLC.

PY - 2020/5/3

Y1 - 2020/5/3

N2 - Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

AB - Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

KW - Autism spectrum disorder

KW - Ecuador

KW - behavior

KW - immunity

KW - microbiota

KW - nutrition

UR - http://www.scopus.com/inward/record.url?scp=85073943227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073943227&partnerID=8YFLogxK

U2 - 10.1080/19490976.2019.1662260

DO - 10.1080/19490976.2019.1662260

M3 - Article

C2 - 31530087

AN - SCOPUS:85073943227

SN - 1949-0976

VL - 11

SP - 453

EP - 464

JO - Gut Microbes

JF - Gut Microbes

IS - 3

ER -

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this