TY - JOUR
T1 - Analysis and neural network modeling of the nonlinear correlates of habituation in the vestibule-ocular reflex
AU - Dow, Ernst R.
AU - Anastasio, Thomas J.
N1 - Funding Information:
We thank Kristen Dempsey, Amy Durkin, Thomedi Ventura, and Mario Zelaya for technical assistance and Dr. Ehtibar Dzhafarov for consultation on statistics. This work was supported by NIH grant MH50577.
PY - 1998
Y1 - 1998
N2 - Through the process of habituation, continued exposure to low-frequency (0.01 Hz) rotation in the dark produced suppression of the low-frequency response of the vestibule-ocular reflex (VOR) in goldfish. The response did not decay gradually, as might be expected from an error-driven learning process, but displayed several nonlinear and nonstationary features. They included asymmetrical response suppression, magnitude-dependent suppression for lower- but not higher-magnitude head rotations, and abrupt-onset suppressions suggestive of a switching mechanism. Microinjection of lidocaine into the vestibulocerebellum of habituated goldfish resulted in a temporary dishabituation. This suggests that the vestibulocerebellum mediates habituation, presumably through Purkinje cell inhibition of vestibular nuclei neurons. The habituated VOR data were simulated with a feed-forward, nonlinear neural network model of the VOR in which only Purkinje cell inhibition of vestibular nuclei neurons was varied. The model suggests that Purkinje cell inhibition may switch in to introduce nonstationarities, and cause asymmetry and magnitude-dependency in the VOR to emerge from the essential nonlinearity of vestibular nuclei neurons.
AB - Through the process of habituation, continued exposure to low-frequency (0.01 Hz) rotation in the dark produced suppression of the low-frequency response of the vestibule-ocular reflex (VOR) in goldfish. The response did not decay gradually, as might be expected from an error-driven learning process, but displayed several nonlinear and nonstationary features. They included asymmetrical response suppression, magnitude-dependent suppression for lower- but not higher-magnitude head rotations, and abrupt-onset suppressions suggestive of a switching mechanism. Microinjection of lidocaine into the vestibulocerebellum of habituated goldfish resulted in a temporary dishabituation. This suggests that the vestibulocerebellum mediates habituation, presumably through Purkinje cell inhibition of vestibular nuclei neurons. The habituated VOR data were simulated with a feed-forward, nonlinear neural network model of the VOR in which only Purkinje cell inhibition of vestibular nuclei neurons was varied. The model suggests that Purkinje cell inhibition may switch in to introduce nonstationarities, and cause asymmetry and magnitude-dependency in the VOR to emerge from the essential nonlinearity of vestibular nuclei neurons.
KW - Cerebellum
KW - Goldfish
KW - Learning
KW - Plasticity
KW - VOR
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U2 - 10.1023/A:1008818016900
DO - 10.1023/A:1008818016900
M3 - Article
C2 - 9617666
AN - SCOPUS:0031970981
SN - 0929-5313
VL - 5
SP - 171
EP - 190
JO - Journal of Computational Neuroscience
JF - Journal of Computational Neuroscience
IS - 2
ER -