Anabolic resistance of muscle protein synthesis with aging

Nicholas A. Burd; Stefan H. Gorissen; Luc J.C. Van Loon

doi:10.1097/JES.0b013e318292f3d5

Anabolic resistance of muscle protein synthesis with aging

Nicholas A. Burd, Stefan H. Gorissen, Luc J.C. Van Loon

Research output: Contribution to journal › Article › peer-review

Abstract

Aging has been associated with a reduced muscle protein synthetic response to protein intake, termed "anabolic resistance." Physical activity performed before protein intake increases the use of protein-derived amino acids for postprandial muscle protein accretion in senescent muscle. Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging.

Original language	English (US)
Pages (from-to)	169-173
Number of pages	5
Journal	Exercise and Sport Sciences Reviews
Volume	41
Issue number	3
DOIs	https://doi.org/10.1097/JES.0b013e318292f3d5
State	Published - Jul 2013
Externally published	Yes

Keywords

amino acids
dietary protein
exercise
mTORC1
sarcopenia

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

Online availability

10.1097/JES.0b013e318292f3d5

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AU - Gorissen, Stefan H.

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AB - Aging has been associated with a reduced muscle protein synthetic response to protein intake, termed "anabolic resistance." Physical activity performed before protein intake increases the use of protein-derived amino acids for postprandial muscle protein accretion in senescent muscle. Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging.

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KW - dietary protein

KW - exercise

KW - mTORC1

KW - sarcopenia

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Anabolic resistance of muscle protein synthesis with aging

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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