Anabolic resistance of muscle protein synthesis with aging

Nicholas A. Burd, Stefan H. Gorissen, Luc J.C. Van Loon

Research output: Contribution to journalArticlepeer-review


Aging has been associated with a reduced muscle protein synthetic response to protein intake, termed "anabolic resistance." Physical activity performed before protein intake increases the use of protein-derived amino acids for postprandial muscle protein accretion in senescent muscle. Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalExercise and Sport Sciences Reviews
Issue number3
StatePublished - Jul 2013
Externally publishedYes


  • amino acids
  • dietary protein
  • exercise
  • mTORC1
  • sarcopenia

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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