@article{6e1a0ac8ff9943b783d3ef5d050eca98,
title = "An Overview of Current Knowledge of the Gut Microbiota and Low-Calorie Sweeteners",
abstract = "This review provides an overview of the interrelationships among the diet, gut microbiota, and health status and then focuses specifically on published research assessing the relationship of low-/no-calorie sweeteners (LNCSs) to selected aspects of the gut microbiota. Microbiome research is expanding as new data on its role in health and disease vulnerability emerge. The gut microbiome affects health, digestion, and susceptibility to disease. In the last 10 years, investigations of LNCS effects on the gut microbiota have proliferated, although results are conflicting and are often confounded by differences in study design such as study diet, the form of the test article, dosage, and study population. Staying current on microbiome research and the role of dietary inputs, such as LNCSs, will allow healthcare and nutrition practitioners to provide evidence-based guidance to the individuals they serve.",
author = "Hughes, {Riley L.} and Davis, {Cindy D.} and Alexandra Lobach and Holscher, {Hannah D.}",
note = "Funding Information: Riley L. Hughes, PhD, is a postdoctoral research associate at the University of Illinois at Urbana-Champaign. Cindy D. Davis, PhD, is the Director of Grants and Extramural Activities, Office of Dietary Supplements, Bethesda, MD. Alexandra Lobach, PhD, is senior manager of Toxicology, Chemistry & Regulatory Affairs; Food and Nutrition, Intertek Health Sciences Inc., Mississauga, ON, Canada. Hannah D. Holscher, PhD, RD, is an assistant professor of Nutrition at the University of Illinois at Urbana-Champaign. R.L.H. and H.D.H. received funding to write the manuscript from the Institute for the Advancement of Food and Nutrition Sciences through an ILSI North America Low-Calorie Sweeteners Committee grant. The Institute for the Advancement of Food and Nutrition Sciences is a nonprofit science organization that pools funding from industry collaborators and advances science through the in-kind and financial contributions from public and private sector participants. C.D.D. and A.L. approved the final version of the article with respect to representation of their webinar content. All authors read and approved the final manuscript. The authors have no conflicts of interest to disclose. Correspondence: Hannah D. Holscher, PhD, RD, 1201 West Gregory Dr, Urbana, IL 61801 (hholsche@illinois.edu). This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Copyright {\textcopyright} 2021 The Authors. Published by Wolters Kluwer Health, Inc. DOI: 10.1097/NT.0000000000000481 Publisher Copyright: {\textcopyright} The Author. Published by Wolters Kluwer Health, Inc.",
year = "2021",
doi = "10.1097/NT.0000000000000481",
language = "English (US)",
volume = "56",
pages = "105--113",
journal = "Nutrition Today",
issn = "0029-666X",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}