TY - JOUR
T1 - An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence
AU - Morin, Charles D.
AU - Déziel, Eric
AU - Gauthier, Jeff
AU - Levesque, Roger C.
AU - Lau, Gee W.
N1 - We thank Justin Parker of the University of Illinois College of Veterinary Medicine for assistance with figure illustration. C.D.M. holds a Ph.D. scholarship from the Fonds de Recherche du Québec– Nature et Technologies (FRQ-NT). Work in the E.D. laboratory is funded by the Canada Research Chairs Program, the Canadian Institute for Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). Work in the R.C.L. laboratory is funded by the Canadian Institute for Health Research (CIHR), Cystic Fibrosis Canada, CIHR-Joint Programming Initiative on Antimicrobial Resistance (JPIAMR), Fonds de Recherche Santé Québec (FRQS)-Respiratory Health Network (QRHN), Genome Canada, Génome Québec and Ontario Genomics. Work in the G.W.L. laboratory is funded by grants from the United States National Institute of Health (R01HL090699, R01AI080710 and R01HL142626) and the American Lung Association DeSouza Research Award (DS-192835-N).
This work was supported by the American Lung Association [DS-192835-N]; Canada Research Chairs; Cystic Fibrosis Canada; Genome Canada; National Heart, Lung, and Blood Institute [R01 HL090699 and R01 HL142626]; National Institute of Allergy and Infectious Diseases [R01 AI080710-06A1]; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Health Research; G?nome Qu?bec and Ontario Genomics; CIHR-Joint Programming Initiative on Antimicrobial Resistance (JPIAMR); Canadian Institute for Health Research (CIHR); Fonds de Recherche Sant? Qu?bec (FRQS)-Respiratory Health Network (QRHN). We thank Justin Parker of the University of Illinois College of Veterinary Medicine for assistance with figure illustration. C.D.M. holds a Ph.D. scholarship from the Fonds de Recherche du Qu?bec? Nature et Technologies (FRQ-NT). Work in the E.D. laboratory is funded by the Canada Research Chairs Program, the Canadian Institute for Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). Work in the R.C.L. laboratory is funded by the Canadian Institute for Health Research (CIHR), Cystic Fibrosis Canada, CIHR-Joint Programming Initiative on Antimicrobial Resistance (JPIAMR), Fonds de Recherche Sant? Qu?bec (FRQS)-Respiratory Health Network (QRHN), Genome Canada, G?nome Qu?bec and Ontario Genomics. Work in the G.W.L. laboratory is funded by grants from the United States National Institute of Health (R01HL090699, R01AI080710 and R01HL142626) and the American Lung Association DeSouza Research Award (DS-192835-N).
PY - 2021
Y1 - 2021
N2 - Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a wide variety of environments, and in the process, making it a notorious opportunistic pathogen. Apart from the extensively studied chronic infection in the lungs of people with cystic fibrosis (CF), P. aeruginosa also causes multiple serious infections encompassing essentially all organs of the human body, among others, lung infection in patients with chronic obstructive pulmonary disease, primary ciliary dyskinesia and ventilator-associated pneumonia; bacteremia and sepsis; soft tissue infection in burns, open wounds and postsurgery patients; urinary tract infection; diabetic foot ulcers; chronic suppurative otitis media and otitis externa; and keratitis associated with extended contact lens use. Although well characterized in the context of CF, pathogenic processes mediated by various P. aeruginosa virulence factors in other organ systems remain poorly understood. In this review, we use an organ system-based approach to provide a synopsis of disease mechanisms exerted by P. aeruginosa virulence determinants that contribute to its success as a versatile pathogen.
AB - Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a wide variety of environments, and in the process, making it a notorious opportunistic pathogen. Apart from the extensively studied chronic infection in the lungs of people with cystic fibrosis (CF), P. aeruginosa also causes multiple serious infections encompassing essentially all organs of the human body, among others, lung infection in patients with chronic obstructive pulmonary disease, primary ciliary dyskinesia and ventilator-associated pneumonia; bacteremia and sepsis; soft tissue infection in burns, open wounds and postsurgery patients; urinary tract infection; diabetic foot ulcers; chronic suppurative otitis media and otitis externa; and keratitis associated with extended contact lens use. Although well characterized in the context of CF, pathogenic processes mediated by various P. aeruginosa virulence factors in other organ systems remain poorly understood. In this review, we use an organ system-based approach to provide a synopsis of disease mechanisms exerted by P. aeruginosa virulence determinants that contribute to its success as a versatile pathogen.
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U2 - 10.1080/21505594.2021.1926408
DO - 10.1080/21505594.2021.1926408
M3 - Review article
C2 - 34180343
AN - SCOPUS:85109698583
SN - 2150-5594
VL - 12
SP - 1469
EP - 1507
JO - Virulence
JF - Virulence
IS - 1
ER -