An ordered comparative map of the cattle and human genomes [2]

Mark Robert Band, Joshua H. Larson, Mark Rebeiz, Cheryl A. Green, D. Wayne Heyen, Jena Donovan, Ryan Windish, Chad Steining, Prapti Mahyuddin, James E. Womack, Harris A. Lewin

Research output: Contribution to journalLetter

Abstract

A cattle-human whole-genome comparative map was constructed using parallel radiation hybrid (RH) mapping in conjunction with EST sequencing, database mining for unmapped cattle genes, and a predictive bioinformatics approach (COMPASS) for targetting specific homologous regions. A total of 768 genes were placed on the RH map in addition to 319 microsatellites used as anchor markers. Of these, 638 had human orthologs with mapping data, thus permitting construction of an ordered comparative map. The large number of ordered loci revealed ≥105 conserved segments between the two genomes. The comparative map suggests that 41 translocation events, a minimum of 54 internal rearrangements, and repositioning of all but one centromere can account for the observed organizations of the cattle and human genomes. In addition, the COMPASS in silico mapping tool was shown to be 95% accurate in its ability to predict cattle chromosome location from random sequence data, demonstrating this tool to be valuable for efficient targeting of specific regions for detailed mapping. The comparative map generated will be a cornerstone for elucidating mammalian chromosome phylogeny and the identification of genes of agricultural importance. ″Ought we, for instance, to begin by discussing each separate species-in virtue of some common element of their nature, and proceed from this as a basis for the consideration of them separately?″ from Aristotle, On the Parts of Animals, 350 B.C.E.

Original languageEnglish (US)
Pages (from-to)1359-1368
Number of pages10
JournalGenome Research
Volume10
Issue number9
DOIs
StatePublished - Oct 13 2000

Fingerprint

Human Genome
Radiation Hybrid Mapping
Mammalian Chromosomes
Genes
Centromere
Expressed Sequence Tags
Phylogeny
Computational Biology
Computer Simulation
Microsatellite Repeats
Chromosomes
Genome
Databases

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Band, M. R., Larson, J. H., Rebeiz, M., Green, C. A., Heyen, D. W., Donovan, J., ... Lewin, H. A. (2000). An ordered comparative map of the cattle and human genomes [2]. Genome Research, 10(9), 1359-1368. https://doi.org/10.1101/gr.145900

An ordered comparative map of the cattle and human genomes [2]. / Band, Mark Robert; Larson, Joshua H.; Rebeiz, Mark; Green, Cheryl A.; Heyen, D. Wayne; Donovan, Jena; Windish, Ryan; Steining, Chad; Mahyuddin, Prapti; Womack, James E.; Lewin, Harris A.

In: Genome Research, Vol. 10, No. 9, 13.10.2000, p. 1359-1368.

Research output: Contribution to journalLetter

Band, MR, Larson, JH, Rebeiz, M, Green, CA, Heyen, DW, Donovan, J, Windish, R, Steining, C, Mahyuddin, P, Womack, JE & Lewin, HA 2000, 'An ordered comparative map of the cattle and human genomes [2]', Genome Research, vol. 10, no. 9, pp. 1359-1368. https://doi.org/10.1101/gr.145900
Band MR, Larson JH, Rebeiz M, Green CA, Heyen DW, Donovan J et al. An ordered comparative map of the cattle and human genomes [2]. Genome Research. 2000 Oct 13;10(9):1359-1368. https://doi.org/10.1101/gr.145900
Band, Mark Robert ; Larson, Joshua H. ; Rebeiz, Mark ; Green, Cheryl A. ; Heyen, D. Wayne ; Donovan, Jena ; Windish, Ryan ; Steining, Chad ; Mahyuddin, Prapti ; Womack, James E. ; Lewin, Harris A. / An ordered comparative map of the cattle and human genomes [2]. In: Genome Research. 2000 ; Vol. 10, No. 9. pp. 1359-1368.
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