An optical, endoscopic brush for high-yield diagnostics in esophageal cancer

S. Anandasabapathy, X. Zhang, M. Anastasio, R. Richards-Kortum, E. Petrova

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Barrett’s esophagus is the main pre-cancer risk factor for the development of esophageal adenocarcinoma. Over the last decades, the incidence rate of esophageal adenocarcinoma increases exponentially in the Western World. Endoscopic screening and minimally-invasive treatment of Barrett’s esophagus are challenging due to large surface area of the lining (1-20 cm). Current microendoscopy technologies have shown high specificity; however, its sensitivity is low due to tiny field-of-view (the probe diameter is 100-1000 µm). Therefore, we proposed a novel approach with end-expandable optical fiber brush to collect endoscopic sparse imaging data and deep learning super-resolution enhancement to provide high yield diagnostics.

Original languageEnglish (US)
Title of host publicationEndoscopic Microscopy XVI
EditorsGuillermo J. Tearney, Thomas D. Wang, Melissa J. Suter
ISBN (Electronic)9781510640757
StatePublished - 2021
EventEndoscopic Microscopy XVI 2021 - Virtual, Online, United States
Duration: Mar 6 2021Mar 11 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceEndoscopic Microscopy XVI 2021
Country/TerritoryUnited States
CityVirtual, Online


  • Barrett’s esophagus
  • Deep learning
  • Endomicroscopy
  • Esophageal cancer
  • Sparse imaging
  • Super-resolution

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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