An intermediate seeks instant gratification

Research output: Contribution to journalShort surveypeer-review


Φ-value analysis of the four-helix protein Im7 reveals that a folding intermediate with non-native structure rapidly forms en route to the native state, even though the protein topology is very simple. Energetic frustration, at least partially induced by functional constraints, appears to play a significant role.

Original languageEnglish (US)
Pages (from-to)154-155
Number of pages2
JournalNature Structural Biology
Issue number3
StatePublished - 2002

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics


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