Abstract
Φ-value analysis of the four-helix protein Im7 reveals that a folding intermediate with non-native structure rapidly forms en route to the native state, even though the protein topology is very simple. Energetic frustration, at least partially induced by functional constraints, appears to play a significant role.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 154-155 |
| Number of pages | 2 |
| Journal | Nature Structural Biology |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2002 |
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Genetics